(hye oh SYE a meen)

Brand Names: U.S.

  • Anaspaz
  • Ed-Spaz
  • HyoMax-SL [DSC]
  • Hyosyne
  • Levbid
  • Levsin
  • Levsin/SL
  • NuLev
  • Oscimin
  • Oscimin SR
  • Symax Duotab
  • Symax FasTabs [DSC]
  • Symax-SL
  • Symax-SR


Use: Labeled Indications


Preoperative antimuscarinic: Preoperative antimuscarinic to reduce salivary, tracheobronchial, and pharyngeal secretions; to reduce volume and acidity of gastric secretions; to block cardiac vagal inhibitory reflexes during induction of anesthesia and intubation

Reversal of neuromuscular blockade and associated muscarinic effects: Protects against peripheral muscarinic effects (such as bradycardia and excessive secretions produced by halogenated hydrocarbons and cholinergic agents [such as physostigmine, neostigmine, and pyridostigmine]) given to reverse actions of curariform agents

Antidote for anticholinesterase agent poisoning: Antidote for poisoning by anticholinesterase agents

Biliary and renal colic: Adjunctive therapy with morphine or other opioids for the symptomatic relief of biliary and renal colic

Diagnostic procedures: Reduces GI motility to facilitate diagnostic procedures such as endoscopy or hypotonic duodenography; may also improve radiologic visibility of the kidneys

GI disorders:

Aid in the control of acute episodes of gastric secretion, visceral spasm, hypermotility in spastic colitis, pylorospasm, and associated abdominal cramps; relieve symptoms in functional intestinal disorders (eg, mild dysenteries, diverticulitis) and infant colic (elixir and oral solution)

Adjunctive therapy for treatment in peptic ulcer; irritable bowel syndrome (irritable colon, spastic colon, acute enterocolitis, mucous colitis) and other functional GI disorders; neurogenic bowel disturbances (including splenic flexure syndrome and neurogenic colon)

Pancreatitis: Reduce pain and hypersecretion in pancreatitis

Parkinsonism: In parkinsonism, to reduce rigidity and tremors and to control associated sialorrhea and hyperhidrosis

Partial heart block: For use in certain cases of partial heart block associated with vagal activity

Rhinitis: “Drying agent” in the relief of symptoms of acute rhinitis

Urinary system disorder: To control hypermotility in spastic bladder and cystitis; adjunctive therapy in the treatment of neurogenic bladder

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