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Acrodermatitis Continua

Daniel R. Matta, DFPHM, FAAFP, MD and Misty L. Gangar, MD Reviewed 05/2023
 


BASICS

  • Acrodermatitis continua of Hallopeau (ACH) is a rare autoimmune disorder that is a variant of localized pustular psoriasis that has a persistent, relapsing course. It is classified as a noninfe...

DIAGNOSIS

The diagnosis is often made clinically and on skin biopsy. Histopathological analysis often reveals intraepidermal spongiform pustules filled with neutrophils.  

HISTORY

  • Symptoms usually start...

TREATMENT

  • ACH is incurable and commonly refractory to treatment. Long-term disease control is commonly needed. There are no standardized treatment algorithms due to the rarity of the disease, however,...

ONGOING CARE

PROGNOSIS

  • Generally persistent, chronically relapsing course

  • May lead to severe disability or complications warranting hospitalization

COMPLICATIONS

  • Association with or progression to PPP or ...

REFERENCES

1
Sugiura  K. The genetic background of generalized pustular psoriasis: IL36RN mutations and CARD14 gain-of-function variants. J Dermatol Sci.  2014;74(3):187–19...

CODES

ICD10

L40.2 Acrodermatitis continua 

SNOMED

  • 200976008 Acrodermatitis continua (disorder)

  • 83839005 Acrodermatitis continua of Hallopeau

  • 58143000 Localized acrodermatitis continua of Hallopeau (disorde...

CLINICAL PEARLS

  • Rare variant of pustular psoriasis that preferentially affects the fingers and toes, often leading to significant pain and loss of function

  • Diagnosis typically made by punch biopsy. The...

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