Acromegaly: a rare endocrinologic disease characterized by excess secretion of growth hormone (GH), resulting in a syndrome of coarsened facial features and overgrowth of the jaw, hands, and fe...
Enlarging shoe and ring size
Vision changes, particularly temporal hemianopsia
Hand numbness/carpal tunnel syndrome
Goals of treatment:
Decrease the serum IGF-1 level to within the reference range for the patient’s age and sex.
Decrease the glucose-suppressed serum GH to <1 ng/mL.
Ameliorate symptoms wi...
Every 3 to 4 months
Cardiovascular exam and BP measurement
Dekkers OM, Biermasz NR, Pereira AM, et al. Mortality in acromegaly: a metaanalysis. J Clin Endocrinol Metab. 2008;93(1):61–67. [View Abstract on OvidMedline]
Melmed S. Medical...
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The onset of acromegaly is insidious and may be initially subtle.
The serum IGF-1 level is the preferred screening test and is elevated in acromegaly.
An elevated IGF-1 should prompt an ...
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The clinical manifestations of acromegaly.
Acromegaly is characterized by enlargement of the facial features (nose, ears) and the hands and feet.