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Amyotrophic Lateral Sclerosis

Grant M. Reed, DO Reviewed 06/2022
 


BASICS

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by muscle weakness and wasting induced from a loss of upper and lower motor neurons in the motor cor...

DIAGNOSIS

Insidious onset of symptoms may result in delay in definitive diagnosis, with median time to diagnosis about 11.5 months. Diagnosis can be established according to revised El Escorial World ...

TREATMENT

GENERAL MEASURES

  • Multidisciplinary care from neurologists, primary care, physical/occupational therapy, speech therapy, respiratory therapy, dietician, case managers should be made available ...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Initially every 3 months; frequency to be increased as needed for symptomatic therapy.

  • Serial pulmonary function tests (PFT) or a maximal sniff n...

REFERENCES

1
Siddique N, Siddique T. Amyotrophic lateral sclerosis overview. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle, WA: University of Washington, Seattle...

CODES

ICD10

  • G12.21 Amyotrophic lateral sclerosis

SNOMED

  • 86044005 Amyotrophic lateral sclerosis

  • 718555006 Juvenile amyotrophic lateral sclerosis

  • 230258005 Amyotrophic lateral sclerosis with dementia

  • 72298700...

CLINICAL PEARLS

  • ALS: progressive degeneration of upper and lower motor neurons.

  • Asymmetric limb weakness is the most common presentation.

  • Diagnosis is based upon clinical criteria, progressive features,...

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