Pancytopenia due to hypocellular bone marrow without the presence of infiltrates or fibrosis; classified as acquired (much more common) and congenital
Acquired aplastic anemia: insidi...
Solvent and radiation history; family, environmental, travel, and infectious disease history
Patients are often asymptomatic but may have frequent infections, fatigue, shortness of bre...
Avoid people who are ill and large crowds.
Wash your hands often, brush and floss your teeth; regular dental care
Pneumonia vaccine and annual flu shot
Aplastic Anemia and M...
Lupus Erythematosus, Systemic (SLE); Myelodysplastic Syndromes (MDS)
Algorithm: Anemia
D61 Other aplastic anemias and other bone marrow failure syndromes
D61.0 Constitutional aplastic anemia
D61.01 Constitutional (pure) red blood cell aplasia
D61.09 Other constitutional aplastic...
Acquired aplastic anemia has an insidious onset and is caused by an exogenous insult triggering an autoimmune reaction. This form is usually responsive to immunosuppressive therapy.
Imm...
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FIGURE 41.7. The peripheral blood smear of refractory anemia with ringed sideroblasts is characterized by a dimorphic red cell population. A distinct population of hypochromic, often microcytic erythrocytes can be found admixed with normochromic, normocytic, or macrocytic erythrocytes.
FIGURE 41.7. The peripheral blood smear of refractory anemia with ringed sideroblasts is characterized by a dimorphic red cell population....
Auer rods CELL TYPE: Myeloblasts and monoblasts (rare) DESCRIPTION: Reddish-purple rod-shaped cytoplasmic inclusions Alignment of primary granules CLINICAL CONDITIONS: M 1 , M 2 , M 3 , M 4 , M 6 CML in blastic transformation Myelodysplastic syndrome--RAEB-IT
Auer rods CELL TYPE: Myeloblasts and monoblasts (rare) DESCRIPTION: Reddish-purple rod-shaped cytoplasmic inclusions Alignment of ...
Iron Deficiency Anemia (IDA) White cells Not remarkable Platelets Normal or slightly increased Red cells Hb and Hct decreased Microcytic, hypochromic anemia Reticulocytes normal or slightly increased Increased RDW Pencil or cigar shaped red cells, codocytes Bone marrow Normoblastic hyperplasia Absent hemosiderin Decreased sideroblasts (less than 10%) Normoblasts are smaller than normal with ragged rims of cytoplasm containing little h...
Iron Deficiency Anemia (IDA) White cells Not remarkable Platelets Normal or slightly increased Red cells Hb and Hct decrease...
Microangiopathic Hemolytic Anemia White cells Not remarkable Platelets Decreased Red cells Normocytic, normochromic anemia Increased reticulocytes Schistocytes Polychromatophilia Peripheral Smear
Microangiopathic Hemolytic Anemia White cells Not remarkable Platelets Decreased Red cells Normocytic, normochromic anemia ...
<bold>FIG. 107.2.</bold> An anteroposterior view of the hips in a 23-year-olf female patient with osteonecrosis of both femoral heads <italic>(arrows)</bold>, associated with systemic lupus erythematosus.
<bold>FIG. 107.2.</bold> An anteroposterior view of the hips in a 23-year-olf female patient with osteonecrosis of both femoral...
<bold>FIG. 107.5.</bold> An anteroposterior view of the knee in a 23-year-old female patient with osteonecrosis of the femoral condyle <italic>(arrow)</bold> associated with systemic lupus erythematosus.
<bold>FIG. 107.5.</bold> An anteroposterior view of the knee in a 23-year-old female patient with osteonecrosis of the femoral ...