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Anemia, Aplastic

Muthalagu Ramanathan, MD Reviewed 06/2020
 


BASICS

DESCRIPTION

  • Pancytopenia due to hypocellular bone marrow without the presence of infiltrates or fibrosis; classified as acquired (much more common) and congenital

  • Acquired aplastic anemia: insidi...

DIAGNOSIS

HISTORY

  • Solvent and radiation history; family, environmental, travel, and infectious disease history

  • Patients are often asymptomatic but may have frequent infections, fatigue, shortness of bre...

TREATMENT

Early treatment increases the chance of success. Two major options: immunosuppressive therapy and hematopoietic stem cell transplantation. Treatment decisions are based on age of the patient...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

patients need to be monitored closely for infection and transfusion support while on immunosuppression 

DIET

If neutropenic, avoid foods that can ...

REFERENCES

1
Luzatto L, Risitano AM. Advances in understanding the pathogenesis of acquired aplastic anaemia. Br J Haematol.  2018;182(6):758–776.

ADDITIONAL READING

SEE ALSO

  • Lupus Erythematosus, Systemic (SLE); Myelodysplastic Syndromes (MDS)

  • Algorithm: Anemia

CODES

ICD10

  • D61 Other aplastic anemias and other bone marrow failure syndromes

  • D61.0 Constitutional aplastic anemia

  • D61.01 Constitutional (pure) red blood cell aplasia

  • D61.09 Other constitutional aplastic...

CLINICAL PEARLS

  • Acquired aplastic anemia has an insidious onset and is caused by an exogenous insult triggering an autoimmune reaction. This form is usually responsive to immunosuppressive therapy.

  • Eti...

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