Autoimmune hemolytic anemia (AIHA): Premature destruction of red blood cells (RBCs) before their normal 120-day life span mediated by autoantibodies against RBC surface antigens (1,...
Symptoms of anemia: fatigue/weakness, palpitations, dyspnea, dizziness (1,2)
Symptoms of hemolysis: jaundice (± dark urine in intravascular hemolysis, e.g., PCH) (1,2,3)
Temperature-r...
Treatment of underlying condition if identified (1,2,3)[C]
Avoidance of triggering agent (1)[C]
Cold weather, cold intravenous (IV) fluids for cold AIHA
Offending medication i...
Serial Hgb measurements to evaluate degree of anemia and/or ongoing hemolysis (1,2,3)[C]
Avoidance of hypothermic fluids, blood products, or sur...
Capeto Coelho I, Aleixo A, Linhares L, et al. Hemolytic anemia potentially associated with aripiprazole. Psychiatry Clin Neurosci. 2018;72(12):87...
Leukemia, Chronic Lymphocytic; Lupus Erythematosus, Systemic (SLE)
Algorithm: Anemia
D59.1 Other autoimmune hemolytic anemias
D59.0 Drug-induced autoimmune hemolytic anemia
413603009 Autoimmune hemolytic anemia (disorder)
309742004 Drug-induced autoimmune hemolytic anemi...
AIHA is a rare cause of anemia, generally diagnosed with a positive DAT assay (Coombs).
In AIHA secondary to an underlying process (e.g., CLL, SLE, EBV, Mycoplasma), treatment of the un...
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FIGURE 41.7. The peripheral blood smear of refractory anemia with ringed sideroblasts is characterized by a dimorphic red cell population. A distinct population of hypochromic, often microcytic erythrocytes can be found admixed with normochromic, normocytic, or macrocytic erythrocytes.
FIGURE 41.7. The peripheral blood smear of refractory anemia with ringed sideroblasts is characterized by a dimorphic red cell population....
Iron Deficiency Anemia (IDA) White cells Not remarkable Platelets Normal or slightly increased Red cells Hb and Hct decreased Microcytic, hypochromic anemia Reticulocytes normal or slightly increased Increased RDW Pencil or cigar shaped red cells, codocytes Bone marrow Normoblastic hyperplasia Absent hemosiderin Decreased sideroblasts (less than 10%) Normoblasts are smaller than normal with ragged rims of cytoplasm containing little h...
Iron Deficiency Anemia (IDA) White cells Not remarkable Platelets Normal or slightly increased Red cells Hb and Hct decrease...
Immune Hemolytic Anemia White cells May be elevated due to an increased in neutrophils Counts may approach 30 X 10<sup>9</sup> /L Platelets Usually normal Red cells Hb and Hct decreased Normocytic, normochromic anemia Reticulocytes increased Increased MCV is due to prominent reticulocytosis Spherocytes Bone marrow Hypercellular with erythroid precursors Peripheral Smear
Immune Hemolytic Anemia White cells May be elevated due to an increased in neutrophils Counts may approach 30 X 10<sup>9</...
Microangiopathic Hemolytic Anemia White cells Not remarkable Platelets Decreased Red cells Normocytic, normochromic anemia Increased reticulocytes Schistocytes Polychromatophilia Peripheral Smear
Microangiopathic Hemolytic Anemia White cells Not remarkable Platelets Decreased Red cells Normocytic, normochromic anemia ...
<bold>FIG. 107.2.</bold> An anteroposterior view of the hips in a 23-year-olf female patient with osteonecrosis of both femoral heads <italic>(arrows)</bold>, associated with systemic lupus erythematosus.
<bold>FIG. 107.2.</bold> An anteroposterior view of the hips in a 23-year-olf female patient with osteonecrosis of both femoral...
<bold>FIG. 107.5.</bold> An anteroposterior view of the knee in a 23-year-old female patient with osteonecrosis of the femoral condyle <italic>(arrow)</bold> associated with systemic lupus erythematosus.
<bold>FIG. 107.5.</bold> An anteroposterior view of the knee in a 23-year-old female patient with osteonecrosis of the femoral ...