Hereditary, hemoglobinopathy marked by chronic hemolytic anemia, acute episodes of painful crises, and increased susceptibility to infections
The heterozygous condition (Hb AS), sickl...
Often asymptomatic in early months of life due to presence of fetal hemoglobin
In those >6 months of age, earliest symptoms are irritability and painful swelling of the hands and fe...
Painful crises: hydration, analgesics; oxygen regardless of whether the patient is hypoxic
Retinal evaluation starting at school age to detect proliferative sickle retinopathy
...
Treat infections early. Parents/patients: Any temperature of ≥101° F (38.3° C) requires immediate medical attention.
Monitor for hepatitis C and ...
D57.212 Sickle-cell/Hb-C disease with splenic sequestration
D57.211 Sickle-cell/Hb-C disease with acute chest syndrome
D57.21 Sickle-cell/Hb-C disease with crisis
D57.01 Hb-SS disease with acu...
The preferred maintenance IV fluid is 1/2 NS because NS may theoretically increase the risk of sickling.
Painful crises in bones, joints, abdomen, back, and viscera account for 90% of a...
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Sickle cell anemia. A peripheral blood smear shows numerous sickled cells, as well as normoblasts and occasional target cells. The erythrocyte to the left of center contains a Howell-Jolly body, indicative of functional hyposplenism.
Sickle cell anemia. A peripheral blood smear shows numerous sickled cells, as well as normoblasts and occasional target cells. The erythro...
FIGURE 41.7. The peripheral blood smear of refractory anemia with ringed sideroblasts is characterized by a dimorphic red cell population. A distinct population of hypochromic, often microcytic erythrocytes can be found admixed with normochromic, normocytic, or macrocytic erythrocytes.
FIGURE 41.7. The peripheral blood smear of refractory anemia with ringed sideroblasts is characterized by a dimorphic red cell population....
FIGURE 10-7.Sickling of red blood cells in sickle cell anemia. (clumped) by anti-A serum; those in type B blood are agglutinated by anti-B serum. Type AB blood cells are agglutinated by both sera, and type O blood is not agglutinated by either serum.
FIGURE 10-7.Sickling of red blood cells in sickle cell anemia. (clumped) by anti-A serum; those in type B blood are agglutinated by anti-B...
Iron Deficiency Anemia (IDA) White cells Not remarkable Platelets Normal or slightly increased Red cells Hb and Hct decreased Microcytic, hypochromic anemia Reticulocytes normal or slightly increased Increased RDW Pencil or cigar shaped red cells, codocytes Bone marrow Normoblastic hyperplasia Absent hemosiderin Decreased sideroblasts (less than 10%) Normoblasts are smaller than normal with ragged rims of cytoplasm containing little h...
Iron Deficiency Anemia (IDA) White cells Not remarkable Platelets Normal or slightly increased Red cells Hb and Hct decrease...
Microangiopathic Hemolytic Anemia White cells Not remarkable Platelets Decreased Red cells Normocytic, normochromic anemia Increased reticulocytes Schistocytes Polychromatophilia Peripheral Smear
Microangiopathic Hemolytic Anemia White cells Not remarkable Platelets Decreased Red cells Normocytic, normochromic anemia ...