Sideroblastic anemia (SA) is a disorder of iron utilization in the erythroblast resulting in ineffective erythropoiesis and variable systemic iron overload leading to anemia. It is c...
Pyridoxine
Will imp...
Annual ferritin and transferrin saturation to monitor for iron overload (2)[A]
Patients given pyridoxine should be followed for response to trea...
Cuijpers ML, van Spronsen DJ, Muus P, et al. Need for early recognition and therapeutic guidelines of congenital sideroblastic anaemia. Int J Hemato...
D64.3 Other sideroblastic anemias
D64.0 Hereditary sideroblastic anemia
D64.1 Secondary sideroblastic anemia due to disease
D64.2 Secondary sideroblastic anemia due to drugs and toxins
41...
SA results from inability to incorporate iron during heme synthesis in the mitochondria, leading to microcytic anemia and sideroblasts in the bone marrow.
Multiple inherited forms are l...
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FIGURE 41.7. The peripheral blood smear of refractory anemia with ringed sideroblasts is characterized by a dimorphic red cell population. A distinct population of hypochromic, often microcytic erythrocytes can be found admixed with normochromic, normocytic, or macrocytic erythrocytes.
FIGURE 41.7. The peripheral blood smear of refractory anemia with ringed sideroblasts is characterized by a dimorphic red cell population....
FIGURE 43.38. Idiopathic refractory sideroblastic anemia with ringed sideroblasts.
FIGURE 43.39. Dimorphic peripheral blood smear in idiopathic refractory sideroblastic anemia.
Iron Deficiency Anemia (IDA) White cells Not remarkable Platelets Normal or slightly increased Red cells Hb and Hct decreased Microcytic, hypochromic anemia Reticulocytes normal or slightly increased Increased RDW Pencil or cigar shaped red cells, codocytes Bone marrow Normoblastic hyperplasia Absent hemosiderin Decreased sideroblasts (less than 10%) Normoblasts are smaller than normal with ragged rims of cytoplasm containing little h...
Iron Deficiency Anemia (IDA) White cells Not remarkable Platelets Normal or slightly increased Red cells Hb and Hct decrease...
Sideroblastic Anemia (SA) White cells Normal to decreased Platelets Not remarkable Red cells Commonly microcytic, hypochromic anemia Dimorphism Increased RDW Reticulocytes normal or slightly increased Basophilic stippling Pappenheimer bodies Bone marrow Erythroid hyperplasia Large numbers of sideroblasts and ringed sideroblasts Increased hemosiderin Increased serum iron Normal or decreased total iron binding capacity (TIBC) Normal or in...
Sideroblastic Anemia (SA) White cells Normal to decreased Platelets Not remarkable Red cells Commonly microcytic, hypochromi...
Microangiopathic Hemolytic Anemia White cells Not remarkable Platelets Decreased Red cells Normocytic, normochromic anemia Increased reticulocytes Schistocytes Polychromatophilia Peripheral Smear
Microangiopathic Hemolytic Anemia White cells Not remarkable Platelets Decreased Red cells Normocytic, normochromic anemia ...