Skip to main content

Antiphospholipid Antibody Syndrome

Krishna Baradhi, MD and Narothama Reddy Aeddula, MD, FACP, FASN Reviewed 06/2019
 


BASICS

DESCRIPTION

Antiphospholipid antibody syndrome (APS) is a systemic autoantibody-mediated thrombophilic disorder characterized by recurrent arterial or venous thrombosis and/or recurrent fetal lo...

DIAGNOSIS

Sapporo criteria (also called Sydney criteria), revised 2006: 
  • At least one of the following clinical criteria:

    • Vascular thrombosis

      • ≥1 clinical episodes of arterial, venous, or small vessel thr...

TREATMENT

MEDICATION

First Line

  • Primary thromboprophylaxis: is controversial in patients with APAs and no clinical symptoms (3)[B]. Low-dose aspirin or heparin is indicated only in patients with high ri...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Standard guidelines for monitoring to maintain INR at therapeutic goal on warfarin therapy

  • Close monitoring is required during pregnancy.

DIET

Hear...

REFERENCES

1
Bertolaccini ML, Amengual O, Andreoli L, et al. 14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends...

ADDITIONAL READING

  • Andrade D, Cervera R, Cohen H, et al. 15th International Congress on Antiphospholipid Antibodies Task Force on antiphospholipd syndrome treatment trends report. In: Erkan D, Lockshi...

CODES

ICD10

  • D68.61 Antiphospholipid syndrome

  • D68.69 Other thrombophilia

  • D68.62 Lupus anticoagulant syndrome

ICD9

  • 289.81 Primary hypercoagulable state

  • 289.82 Secondary hypercoagulable state

SNOMED

  • 26843008 ant...

CLINICAL PEARLS

  • APS is a multisystem autoimmune disorder with recurrent arterial/venous thrombosis and fetal loss and positive APAs.

  • Both clinical and laboratory criteria are required for diagnosis. Th...

Subscribe to Access Full Content

Sign Up for a 10-Day Free Trial

Sign up for a 10-day FREE Trial now and receive full access to all content.

×