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Antiphospholipid Antibody Syndrome

Juliana Chang, MD Reviewed 04/2024
 


BASICS

DESCRIPTION

Antiphospholipid antibody syndrome (APS) is a systemic autoantibody-mediated thrombophilic disorder characterized by recurrent arterial or venous thrombosis and/or recurrent fetal lo...

DIAGNOSIS

Sapporo criteria (also called Sydney criteria), revised 2006: 
  • At least one of the following clinical criteria:

    • Vascular thrombosis

      • ≥1 clinical episodes of arterial, venous, or small vessel thr...

TREATMENT

MEDICATION

First Line

  • Primary thromboprophylaxis: is controversial in patients with APS and no clinical symptoms. A 2018 Cochrane review involving nine studies and 1,044 randomized participant...

ONGOING CARE

DIET

Patients on warfarin should limit foods rich in vitamin K (kale, spinach, sprouts, greens). 

PATIENT EDUCATION

  • Compliance with warfarin therapy to keep INR at goal

  • Awareness of drug and ...

REFERENCES

1
Bertolaccini  ML, Amengual  O, Andreoli  L, et al. 14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome labora...

CODES

ICD10

  • D68.61 Antiphospholipid syndrome

  • D68.69 Other thrombophilia

  • D68.62 Lupus anticoagulant syndrome

SNOMED

  • 26843008 antiphospholipid syndrome (disorder)

  • 239892009 Primary antiphospholipid syndrome

  • 23...

CLINICAL PEARLS

  • APS is a multisystem autoimmune disorder with recurrent arterial/venous thrombosis and fetal loss and positive APAs.

  • Both clinical and laboratory criteria are required for diagnosis. Th...

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