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Antiphospholipid Antibody Syndrome

Reviewed 06/2022
 


BASICS

DESCRIPTION

Antiphospholipid antibody syndrome (APS) is a systemic autoantibody-mediated thrombophilic disorder characterized by recurrent arterial or venous thrombosis and/or recurrent fetal lo...

DIAGNOSIS

Sapporo criteria (also called Sydney criteria), revised 2006: 
  • At least one of the following clinical criteria:

    • Vascular thrombosis

      • ≥1 clinical episodes of arterial, venous, or small vessel thr...

TREATMENT

MEDICATION

First Line

  • Primary thromboprophylaxis: is controversial in patients with APS and no clinical symptoms (3)[B]. A 2018 Cochrane review involving nine studies and 1,044 randomized par...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Standard guidelines for monitoring to maintain INR at therapeutic goal on warfarin therapy

  • Close monitoring is required during pregnancy.

DIET

Hear...

REFERENCES

1
Bertolaccini  ML, Amengual  O, Andreoli  L, et al. 14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome labora...

ADDITIONAL READING

de Jesús GR, Benson AE, Chighizola CB, et al. 16th International Congress on Antiphospholipid Antibodies Task Force Report on Obstetric Antiphospholipid Syndrome. ...

CODES

ICD10

  • D68.61 Antiphospholipid syndrome

  • D68.69 Other thrombophilia

  • D68.62 Lupus anticoagulant syndrome

SNOMED

  • 26843008 antiphospholipid syndrome (disorder)

  • 239892009 Primary antiphospholipid syndrome

  • 23...

CLINICAL PEARLS

  • APS is a multisystem autoimmune disorder with recurrent arterial/venous thrombosis and fetal loss and positive APAs.

  • Both clinical and laboratory criteria are required for diagnosis. Th...

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