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Antithrombin Deficiency

John David Peterson, DO Reviewed 05/2023
 


BASICS

DESCRIPTION

  • Antithrombin deficiency results in an increased incidence of venous thromboembolism (VTE), but not arterial thrombosis.

  • Antithrombin is a non-vitamin K dependent protease inhibitor pr...

DIAGNOSIS

HISTORY

  • Previous VTE

  • Family history of VTE or antithrombin deficiency

  • VTE at uncommon sites (upper limb, mesenteric, renal, retinal veins)

PHYSICAL EXAM

Signs consistent with a deep or superficia...

TREATMENT

GENERAL MEASURES

Tobacco cessation, maintaining healthy body weight, avoiding prolonged immobilization, avoidance of hormonal contraception and hormonal therapies  (2)[C

MEDICATION

  • Routine an...

ONGOING CARE

  • Those with recurrent DVT require lifelong anticoagulation (2).

  • Asymptomatic patients do not require anticoagulation except in temporary circumstances (i.e., surgery).

FOLLOW-UP RECOMMENDATIONS

REFERENCES

1
National Organization for Rare Disorders. Antithrombin deficiency. 2018, rarediseases.org/rare-diseases/antithrombin-deficiency/. Accessed March 31, 2023.
2
Maclean  P...

SEE ALSO

Deep Vein Thrombosis 

CODES

ICD10

D68.59 Other primary thrombophilia 

SNOMED

  • 36351005 Antithrombin III deficiency (disorder)

  • 439699000 hereditary antithrombin III deficiency (disorder)

  • 439126002 Thrombophilia due to acquired an...

CLINICAL PEARLS

  • Antithrombin deficiency can result in an increased incidence of venous thromboembolism, including atypical locations such as upper limb veins, vena cava, and renal veins. Arterial thro...

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