Also known as giant cell arteritis (GCA), Horton disease, and cranial arteritis
Temporal arteritis is a chronic inflammatory disease involving large- and medium-sized arteries, most ...
Most common presenting symptom is headache (2/3 of patients).
Constitutional symptoms (fever, fatigue, weight loss)
Any visual disturbances (amaurosis fugax, diplopia)
Vision loss (20% o...
The typical dose of prednisone is between 60 and 80 mg/day (or 1 mg/kg/day), and the dose may be titrated up to relieve symptoms. Steroids should not be ...
GCA is ...
M31.6 Other giant cell arteritis
M31.5 Giant cell arteritis with polymyalgia rheumatica
400130008 Temporal arteritis (disorder)
414341000 giant cell arteritis (disorder)
239938009 Giant c...
Due to the risk of irreversible vision loss, treatment with high-dose steroids (prednisone 60 mg/day) should be started immediately in patients suspected of GCA.
Temporal artery biopsy ...
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<bold>FIG. 75.3.</bold> Histopathology of inflammatory myopathies. A,B: Muscle biopsies from polymyositis patients tend to show focal endomysial infiltration by mononuclear cells (A: hematoxylin and eosin stain), while those from dermatomyositis patients show more perivascular and interstitial inflammation with perifascicular myofiber atrophy (B: modified trichrome stain). C: Transverse fresh-frozen section of muscle from a patient with inclusion body myositis displaying purplish granular materia...
<bold>FIG. 75.3.</bold> Histopathology of inflammatory myopathies. A,B: Muscle biopsies from polymyositis patients tend to sho...
Antidepressant drugs and the biochemical life cycles of norepinephrine and serotonin. MAO inhibitors, tricyclics, and SSRIs are used as antidepressants. MAO inhibitors enhance the actions of NE and 5-HT by preventing their enzymatic destruction. Tricyclics enhance NE and 5-HT action by blocking uptake. SSRIs act the same way but are selective for serotonin.
Antidepressant drugs and the biochemical life cycles of norepinephrine and serotonin. MAO inhibitors, tricyclics, and SSRIs are used as ant...