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Aspergillosis

Frances J Boly, DO and Sarah Jaber, Doctor of Osteopathic Medicine Reviewed 06/2022
 


BASICS

DESCRIPTION

  • Aspergillosis refers to illness due to allergy, airway/lung invasion, cutaneous infection, or extrapulmonary dissemination caused by a mold, Aspergillus. Most commonly, it is caused ...

DIAGNOSIS

HISTORY

  • Symptoms depend on the site of infection and may include fever, dyspnea, cough, sinus congestion/pain.

  • Symptoms of ABPA present as recurrent asthma exacerbations. In severe cases, feve...

TREATMENT

GENERAL MEASURES

  • ABPA may improve with allergen avoidance and optimal asthma control.

  • Depending on the clinical picture, treatment of aspergilloma may include observation, oral antifungal ther...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • During therapy, Aspergillus IgG and inflammatory markers should be repeated every 3 months and chest radiographs should be monitored every 6 to 12 months. CT scan...

REFERENCES

1
Agarwal  R, Chakrabarti  A, Shah  A, et al. Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria...

ADDITIONAL READING

  • Patterson KC, Strek ME. Diagnosis and treatment of pulmonary aspergillosis syndromes. Chest. 2014;146(5):1358–1368. https://doi.org/10.1378/chest.14-0917 ...

CODES

ICD10

  • B44.9 Aspergillosis, unspecified

  • B44.1 Other pulmonary aspergillosis

  • B44.81 Allergic bronchopulmonary aspergillosis

  • B44.89 Other forms of aspergillosis

  • B44.0 Invasive pulmonary aspergillosis

  • B44...

CLINICAL PEARLS

  • Although Aspergillus spp. are ubiquitous, most immunocompetent people do not acquire disease.

  • Diagnosis of aspergillosis can be challenging and is based on history, physical exam, and a...

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