Metaplasia of the distal esophageal mucosa from native stratified squamous epithelium to abnormal columnar (intestinalized) epithelium; likely a consequence of chronic GERD
Assess underlying risk factors.
Common GERD symptoms: heartburn, regurgitation
Atypical symptoms include chest pain, odynophagia, chronic cough, water brash, globus sensation, laryngiti...
The goal of medical therapy is to control GERD and reduce esophagitis.
Neither suppression of gastric acid production via high-dose PPIs nor reduction in esophageal acid exposure vi...
Surveillance (to detect high-grade dysplasia or early carcinoma), although controversial, is recommended in patients with histologically confirmed BE, especially ...
Dunbar KB, Spechler SJ. Controversies in Barrett esophagus. Mayo Clin Proc. 2014;89(7):973–984. [View Abstract on OvidMedline]
K22.70 Barrett’s esophagus without dysplasia
K22.719 Barrett’s esophagus with dysplasia, unspecified
K22.710 Barrett’s esophagus with low grade dysplasia
K22.711 Barrett’s esophagus with high ...
The incidence of esophageal cancer is rising faster than any other major malignancy. BE is a precursor to esophageal carcinoma.
The highest incidence of BE is in white males >50 year...
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Major malignant tumors of the gastrointestinal tract.
Gastroesophageal disorders and digestive anatomy, dentate line, Barrett's esophagus.
<bold>Fig GI 4-4 Barrett esophagus.</bold> Ulcerations (arrow) have developed at a distance from the esophagogastric junction.
<bold>Fig GI 5-6 Barrett esophagus.</bold> Smooth stricture in the upper thoracic esophagus.
Figure 21-8. A: Low-power picture of an invasive cancer at the cardioesophageal junction (open arrow). It is bordered by a metaplastic Barrett's mucosa (closed arrow) arranged in villus folds. B: Detail of intestinal-type epithelium with many goblet cells on the surface of these folds. The core of one fold is invaded by the carcinoma (arrow).
Figure 21-8. A: Low-power picture of an invasive cancer at the cardioesophageal junction (open arrow). It is bordered by a metaplastic Bar...
<bold><italic>Figure 15-9</bold> Barrett esophagus.</bold> Normal esophagus is lined by layers of flat, squamous epithelium. Normal stomach is lined by tall, columnar cells. Chronic reflux of gastric acid evokes change (metaplasia) of normal esophageal squamous epithelium into gastric epithelium (Barrett metaplasia). Esophageal ulcers and adenocarcinoma may arise in areas of Barrett metaplasia.
<bold><italic>Figure 15-9</bold> Barrett esophagus.</bold> Normal esophagus is lined by layers of flat, squamous e...
Gastroesophageal Reflux Disease (GERD) Labeled
Gastroesophageal Junction and Squamocolumnar Junction Unlabeled
Gastroesophageal Junction and Squamocolumnar Junction Labeled
Squamocolumnar Junction Unlabeled
Squamocolumnar Junction Labeled