A paralytic illness caused by a neurotoxin produced by the anaerobic bacterium Clostridium botulinum
Characterized by acute onset of cranial nerve dysfunction (diplopia, difficulty sw...
Adults
Acute onset of cranial nerve dysfunction
IV drug use, skin-popping, or cocaine use (wound botulism)
Retains normal mental state; no fever or sensory dysfunction
Infant botulism: ...
Antitoxin therapy with trivalent A-B-E antitoxin (4)[A]
Initiate botulinum antitoxin therapy based on symptoms and physical examination findings.
Early administration is ...
Pulmonary function testing
Cardiorespira...
A05.1 Botulism food poisoning
A48.52 Wound botulism
A48.51 Infant botulism
005.1 Botulism food poisoning
040.42 Wound botulism
040.41 Infant botulism
398565003 Infection due to clostrid...
Botulism is primarily diagnosed on clinical grounds.
Administer botulinum antitoxin as soon as botulism is suspected.
Report suspected cases to public health authorities.
The “dozen D’s” ...
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Clostridial diseases. Clostridia in the vegetative form inhabit the gastrointestinal tract of humans and animals. Spores pass in the feces, contaminate soil and plant materials, and are ingested or enter sites of penetrating wounds. Under anaerobic conditions they revert to vegetative forms. Plasmids in the vegetative forms elaborate toxins that cause several clostridial diseases. Food poisoning and necrotizing enteritis. Meat dishes left to cool at room temperature grow large numbers of cl...
Clostridial diseases. Clostridia in the vegetative form inhabit the gastrointestinal tract of humans and animals. Spores pass in the feces...
<bold><italic>Figure 15-20</bold> Mechanisms of bacterial enterocolitis.</bold> Diarrhea can be caused by (<bold>A</bold>) bacterial toxin formed in food before ingestion, (<bold>B</bold>) toxin formed in the intestinal tract after infection, or (<bold>C</bold>) direct invasion of infective organisms in the bowel wall.
<bold><italic>Figure 15-20</bold> Mechanisms of bacterial enterocolitis.</bold> Diarrhea can be caused by (<bol...