Rare, highly morbid, obliterative vasculopathy, characterized by ischemic or necrotic skin lesions
Affects patients with end-stage renal disease (ESRD): calcific uremic arteriolopathy...
Diagnosis is primarily based on clinical suspicion with characteristic skin findings in ESRD patients with risk factors.
Based on expert opinion, an interdisciplinary approach is recommended ...
Aggressive control of Ca, P, and PTH (2)[C]
Pharmacologic mobilization/solubilization of Ca from involved tissue
Chelation of Ca and P by IV thiosulfate (emerging as a standard of care based o...
High morbidity and mortality
Infectious morbidity within weeks of diagnosis and death within months are common.
1-Year mortality 45–80%
Higher mortality with ulcerative lesions (6...
el-Azhary RA, Arthur AK, Davis MD, et al. Retrospective analysis of tissue plasminogen activator as an adjuvant treatment for calciphylaxis. JAMA Dermatol. 2013;149(1):63–67. ...
Calciphylaxis is a highly morbid systemic condition of uncertain pathogenesis, primarily affecting the skin that is almost unique to the ESRD population, often confused with ulcerative...
Sign up for a 10-day FREE Trial now and receive full access to all content.