Rare, highly morbid, obliterative vasculopathy, characterized by ischemic or necrotic skin lesions
Uremic calciphylaxis (more common): calciphylaxis in patients with renal failure nea...
Diagnosis is primarily based on clinical suspicion with characteristic skin findings in ESRD patients with risk factors.
Lab studies are not useful for diagnostic purposes.
Imaging studies dem...
Multidisciplinary approach involving nephrology, dermatology, dermatopathology, wound care, nutrition, pain management, palliative medicine, plastic surgery
Aggressive control...
High morbidity and mortality
Infectious morbidity within weeks of diagnosis and death within months are common.
1-year mortality 45–80%
Higher mortality with ulcerative lesions (65–...
el-Azhary RA, Arthur AK, Davis MD, et al. Retrospective analysis of tissue plasminogen activator as an adjuvant treatment for calciphylaxis. JAMA Derma...
Calciphylaxis is a highly morbid systemic condition of uncertain pathogenesis, primarily affecting the skin that is almost unique to the ESRD population, often confused with ulcerative...
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