Rare, highly morbid, obliterative vasculopathy, characterized by ischemic or necrotic skin lesions
Affects patients with end-stage renal disease (ESRD)—calcific uremic arteriolopathy ...
Diagnosis is primarily clinical by characteristic skin findings in ESRD patients with risk factors.
Lab studies are not useful for diagnostic purposes.
Imaging studies demonstrating tissue cal...
No FDA medications specifically approved for calciphylaxis
Aggressive control of Ca, P, and PTH (2)[C]
Pharmacologic mobilization/solubilization of Ca from involved tissue
Chelation of Ca and P...
High morbidity and mortality
Infectious morbidity within weeks of diagnosis and death within months are common.
1-Year mortality 45–80%
Higher mortality with ulcerative lesions (65–...
Araya CE, Fennell RS, Neiberger RE, et al. Sodium thiosulfate treatment for calcific uremic arteriolopathy in children and young adults. Clin J Am Soc Nephrol. 2006;1(6):1161–...
Calciphylaxis is a highly morbid systemic condition of uncertain pathogenesis, primarily affecting the skin that is almost unique to the ESRD population, often confused with ulcerative...
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