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Candidiasis, Invasive

Saira Ajmal, MD and Mohammed Zaid Siddiqui, MS, DO Reviewed 06/2022
 


BASICS

DESCRIPTION

Candida albicans and related species cause a variety of infections. Noninvasive candidal infections are common and can take many forms including esophagitis, vaginitis, onychomycosis...

DIAGNOSIS

HISTORY

  • Fever unresponsive to broad-spectrum antibiotics in patients at high risk for invasive candidiasis

  • Prolonged central venous catheterization

  • Symptoms are often nonspecific, need to have ...

TREATMENT

Inpatient care is recommended for hematogenously disseminated invasive candidiasis. 

GENERAL MEASURES

  • Begin empiric therapy (5)[C]

  • Remove all intravenous catheters if possible. Removing central...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Obtain follow-up blood cultures for all patients with candidemia to ensure eradication from the bloodstream.

PATIENT EDUCATION

Advise patients of ...

REFERENCES

1
Horn, D. L., Neofytos, D., Anaissie, E. J., Fishman, J. A., Steinbach, W. J., Olyaei, A. J., ... & Webster, K. M. (2009). Epidemiology and outcomes of candidemia in 2019 patients: data...

ADDITIONAL READING

  • Chalmers  C, Gaur  S, Chew  J, et al. Epidemiology and management of candidaemia—a retrospective, multicentre study in five hospitals in the UK. Mycoses. ...

CODES

ICD10

  • B37.7 Candidal sepsis

  • P37.5 Neonatal candidiasis

  • B37.89 Other sites of candidiasis

  • B37.0 Candidal stomatitis

  • B37.49 Other urogenital candidiasis

  • B37.2 Candidiasis of skin and nail

  • B37.9 Candidias...

CLINICAL PEARLS

  • Consider invasive candidemia in high-risk febrile patients not responding to appropriate antibiotic treatment.

  • Start antifungal therapy on all candidemic patients within 24 hours of a p...

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