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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (CFS)

Grant M. Reed, DO and Jessica Lowry, PhD Reviewed 06/2020
 


BASICS

DESCRIPTION

  • A chronic and complex physical illness characterized by a new or definitive onset of debilitating fatigue that persists for >6 months and significantly reduces a person’s ability ...

DIAGNOSIS

HISTORY

A thorough medical history and psychosocial history is required for an accurate diagnosis. The 2015 diagnostic criteria proposed by the Institute of Medicine (IOM) (1) require three s...

TREATMENT

  • No treatment has been proven effective by large randomized trials; recommendations are based on expert opinion and standard symptom management (e.g., sleep disturbances, depression, and pain...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

Although no consensus exists, periodic reevaluation is appropriate for support, relief of symptoms, and assessment for other possible causes of ...

REFERENCES

1
Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Board on the Health of Select Populations, Institute of Medicine. Beyond Myalgic Encephalomyeli...

ADDITIONAL READING

Kashi AA, Davis RW, Phair RD. The IDO metabolic trap hypothesis for the etiology of ME/CFS. Diagnostics (Basel).  2019;9(3):pii: E82. 

SEE ALSO

Algorithm: Fatigue 

CODES

ICD10

R53.82 Chronic fatigue, unspecified 

ICD9

780.71 Chronic fatigue syndrome 

SNOMED

52702003 Chronic fatigue syndrome (disorder) 

CLINICAL PEARLS

  • No pharmacologic agents (e.g., antidepressants, immune modulators) have been shown to be consistently effective in treating CFS.

  • There are many more patients with idiopathic chronic fat...

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