Primary Biliary Cholangitis (PBC) is an autoimmune disease characterized by chronic progressive destruction of small intrahepatic bile ducts with portal inflammation resulting in fib...
20-60% of patients are asymptomatic at diagnosis (1).
Often identified by incidental finding of elevated serum alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GGTP), or total s...
UDCA improves transplant-free survival. When started early, overall survival approaches the general population's.
The optimal dose is 13 to 15 mg/kg/day and no dose escala...
Vaccinate nonimmune patients against hepatitis A and hepatitis B.
Decrease alcohol intake and optimize weight management. Avoid hepatotoxic drugs.
Pregnant women ne...
Consider PBC in middle-aged women with unexplained pruritus or asymptomatic elevation of ALP.
AMA is positive in 95% of cases. Consider liver biopsy if AMA is negative or AST is >5 t...
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