Primary Biliary Cholangitis (PBC) is a chronic autoimmune disease characterized by the destruction of intrahepatic cholangiocytes and progressive cholestasis. The diagnostic hallmark...
20–60% of patients are asymptomatic at diagnosis (1).
Often identified by incidental finding of elevated serum alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GGTP), or total s...
UDCA improves transplant-free survival. When started early, overall survival approaches the general population's [A].
The optimal dose is 13 to 15 mg/kg/day. It does not a...
Vaccinate nonimmune patients against hepatitis A and hepatitis B.
Decrease alcohol intake and optimize weight management. Avoid hepatotoxic drugs.
Pregnant women ne...
Consider PBC in middle-aged women with unexplained pruritus or asymptomatic elevation of ALP.
AMA is positive in 95% of cases. Consider liver biopsy if AMA is negative or AST is >5 t...
Sign up for a 10-day FREE Trial now and receive full access to all content.