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Coccidioidomycosis

Maria M. Plummer, MD and Charles Pavia, PhD Reviewed 06/2019
 


BASICS

DESCRIPTION

  • A pulmonary fungal infection caused by the dimorphic fungus, Coccidioides immitis, which is endemic to the southwestern deserts of the United States:

    • Transmitted through inhalation ...

DIAGNOSIS

HISTORY

  • Travel history is essential in pulmonary disease that does not respond to normal treatments.

  • Most humans infected with coccidioidomycosis are asymptomatic or have minimal symptoms (4).

  • ...

TREATMENT

GENERAL MEASURES

  • Cool mist humidifier for dry cough or sore throat, antitussives

  • Supportive therapy

  • Most cases resolve without antifungal treatment.

MEDICATION

First Line

  • In mild cases, treatment ...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • If serology is negative but index of suspicion is high, repeat every 2 weeks.

  • With positive serology, follow titers every 2 weeks until are dropp...

REFERENCES

1
Thompson GRIII. Pulmonary coccidioidomycosis. Semin Respir Crit Care Med.  2011;32(6):754–763. [View Abstract on OvidMedline]
2
Ruddy BE, Mayer AP, Ko MG, et al. Coccidioidomycosis in A...

ADDITIONAL READING

  • Ramos-e-Silva M, Lima CM, Schechtman RC, et al. Systemic mycoses in immunodepressed patients (AIDS). Clin Dermatol.  2012;30(6):616–627. [View Abstract on OvidMedline]

  • Szeyko LA...

CODES

ICD10

  • B38.9 Coccidioidomycosis, unspecified

  • B38.2 Pulmonary coccidioidomycosis, unspecified

  • B38.0 Acute pulmonary coccidioidomycosis

  • B38.1 Chronic pulmonary coccidioidomycosis

  • B38.89 Other forms of c...

CLINICAL PEARLS

  • Consider coccidioidomycosis in patients who have traveled to or live in endemic areas presenting with persistent pulmonary symptoms that do not respond to routine treatment.

  • Minimal exp...

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