Cryoglobulinemia

Cryoglobulins (CGs) are proteins that precipitate in serum and plasma at cold temperatures 98.6°F (<37°C) and redissolve at body temperature (1).

CGs are a mixture of immunoglobul...

Type I

• Commonly asymptomatic

• More frequent association with signs of peripheral vessel occlusion (e.g., Raynaud phenomenon, acrocyanosis, livedo reticularis, purpura, ulcers, gangrene), less w...

Goals:

• Symptomatic management of vasculitis and/or hyperviscosity and limit damage caused by circulating immune complexes

• Limit or suppress B-lymphocyte proliferation.

• Eradicate HCV (if applica...

30911005 cryoglobulinemia (disorder)

38675009 Monoclonal cryoimmunoglobulinemia (disorder)

44371002 Mixed polyclonal cryoimmunoglobulinemia (disorder)

Type I: associated with lymphoproliferative disorders (e.g., multiple myeloma, Waldenström macroglobulinemia, monoclonal gammopathy of undetermined significance, and chronic lymphocyti...