Cryoglobulinemia

Cryoglobulins (CGs) consist of immunoglobulins (Igs) and complement precipitating in serum and plasma.

CGs precipitate at cold temperatures 98.6°F (<37°C) and dissolve on rewarming...

Type I

• Commonly asymptomatic

• More frequent association with signs of peripheral vessel occlusion (e.g., Raynaud phenomenon, acrocyanosis, livedo reticularis, purpura, ulcers, gangrene), less w...

Goals:

• Symptomatic management of vasculitis and/or hyperviscosity and limit damage caused by circulating immune complexes

• Limit or suppress B-lymphocyte proliferation.

• Eradicate HCV (if applica...

Alpers  CE, Smith  KD. Cryoglobulinemia and renal disease. Curr Opin Nephrol Hypertens.  2008; 17(3): 243– 249.

...

30911005 cryoglobulinemia (disorder)

38675009 Monoclonal cryoimmunoglobulinemia (disorder)

44371002 Mixed polyclonal cryoimmunoglobulinemia (disorder)

CGs are circulating Igs that precipitate at cold temperatures (below 37°C) and dissolve on rewarming.

Type I: associated with lymphoproliferative disorders (e.g., multiple myeloma, Wald...