Cryoglobulins (CGs) consist of immunoglobulins (Igs) and complement precipitating in serum and plasma.
CGs precipitate at cold temperatures 98.6°F (<37°C) and dissolve on rewarming...
Triad: palpable purpura, arthralgia, myalgia
Type I
Commonly asymptomatic
More frequent association with signs of peripheral vessel occlusion (e.g., Raynaud phenomenon, acrocyanosis, livedo ret...
Goals:
Symptomatic management of vasculitis and/or hyperviscosity and limit damage caused by circulating immune complexes
Limit or suppress B-lymphocyte proliferation.
Eradicate HCV (if applica...
Alpers CE, Smith KD. Cryoglobulinemia and renal disease. Curr Opin Nephrol Hypertens. 2008;17(3):243–249.
Anis S, Abbas K, Mubarak M, et al. Vasculitis with renal involvement i...
30911005 cryoglobulinemia (disorder)
38675009 Monoclonal cryoimmunoglobulinemia (disorder)
44371002 Mixed polyclonal cryoimmunogl...
CGs are circulating Igs that precipitate at cold temperatures (below 37°C) and dissolve on rewarming.
Type I: associated with lymphoproliferative disorders (e.g., multiple myeloma, Wald...
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