Major invasive fungal infection, caused by encapsulated yeasts
There are >30 different species of Cryptococcus. Two species cause nearly all cryptococcal disease in humans—Cryptoco...
Cryptococcal meningitis
Insidious onset, subtle findings such as impaired mentation, lethargy, or memory loss in immunosuppressed patients
Immunocompetent patients may have fluctuatin...
Treat based on immune status and disease stage.
Treat Cryptococcus prior to initiating HAART therapy in HIV-infected patients to avoid immune reconstitution inflammatory syndrome (I...
In immunosuppressed patients with cryptococcal meningitis, lifelong secondary prophylaxis is generally required for suppression:
Without suppre...
Gullo FP, Rossi SA, Sardi Jde C, et al. Cryptococcosis: epidemiology, fungal resistance, and new alternatives for treatment. Eur J Clin Microbiol Infect Dis. 2013;32(11):1377–...
B45.9 Cryptococcosis, unspecified
B45.1 Cerebral cryptococcosis
B45.0 Pulmonary cryptococcosis
B45.2 Cutaneous cryptococcosis
B45.3 Osseous cryptococcosis
B45.7 Disseminated cryptococcosis
B45.8 ...
Cryptococcal meningitis is not spread from person to person.
Skin nodules imply disseminated disease. When discovered, look for CNS and pulmonary involvement and treat accordingly.
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