Major invasive fungal infection, caused by encapsulated yeasts
There are >30 different species of Cryptococcus. Two species cause nearly all cryptococcal disease in humans—Cryptoco...
Insidious onset, subtle findings such as impaired mentation, lethargy, or memory loss in immunosuppressed patients
Immunocompetent patients may have fluctuating ...
Treat based on immune status and disease stage.
Treat Cryptococcus prior to initiating HAART in HIV-infected patients to avoid immune reconstitution inflammatory syndrome (IRIS).
In immunosuppressed patients with cryptococcal meningitis, lifelong secondary prophylaxis is generally required for suppression:
Boulware DR, Meya DB, Muzoora C, et al; for COAT Trial Team. Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis.
N Engl J Med. 2014;370...
B45.1 Cerebral cryptococcosis
B45.7 Disseminated cryptococcosis
B45.0 Pulmonary cryptococcosis
B45.3 Osseous cryptococcosis
B45.8 Other forms of cryptococcosis
B45.2 Cutaneous ...
Cryptococcal meningitis is not spread from person to person.
Skin nodules imply disseminated disease. When present, examine for CNS and pulmonary involvement and treat accordingly.
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