Skip to main content

Cushing Disease and Cushing Syndrome

Dana M Vlachos, DO Reviewed 04/2024
 


BASICS

DESCRIPTION

  • Cushing syndrome is defined as excessive glucocorticoid exposure from exogenous sources (such as steroids) or less commonly from endogenous sources (i.e., pituitary, adrenal, pulmona...

DIAGNOSIS

  • The most common age at diagnosis ranges from ages 30 to 49 years, but Cushing Syndrome can be diagnosed from the ages of 5 to 75 years.

  • Symptoms may include facial plethora, round face, dorso...

TREATMENT

  • For patients with endogenous Cushing Syndrome, the primary aim of therapy is complete resection of the underlying tumor.

  • For patients with Cushing Disease, the primary therapy is transsphenoi...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Once treated, the physical signs/symptoms of Cushing Disease/Syndrome gradually disappear over a period of 2–12 months. Obesity, hypertension, g...

REFERENCES

1
Nieman LK, Biller BMK, Findling JW, et al. Treatment of Cushing’s syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2015;100:2807–2831.
2
Nieman LK, Ilias ...

SEE ALSO

Algorithm: Cushing Syndrome 

CODES

ICD10

  • E24.9 Cushing’s syndrome, unspecified

  • E24.0 Pituitary-dependent Cushing’s disease

  • E24.2 Drug-induced Cushing’s syndrome

  • E24.8 Other Cushing’s syndrome

  • E24.4 Alcohol-induced pseudo-Cushing’s syn...

CLINICAL PEARLS

  • Cushing disease is due to excessive ACTH secretion from a pituitary tumor.

  • Cushing syndrome is due to excessive corticosteroid exposure from exogenous sources (medications) or endogenou...

Subscribe to Access Full Content

Sign Up for a 10-Day Free Trial

Sign up for a 10-day FREE Trial now and receive full access to all content.

 
×