Cushing Disease and Cushing Syndrome

Clinical abnormalities associated with chronic exposure to excessive amounts of cortisol (the major adrenocorticoid)

Cushing syndrome is defined as excessive corticosteroid exposure f...

Weight gain: 95%

Decreased libido: 90%

Menstrual irregularity: 80%

Depression/emotional lability: 50–80%

Easy bruising: 95%

Diabetes or glucose intolerance: 90%

Obesity (usuall...

Drugs usually not effective for primary long-term treatment; used in preparation for surgery or as adjunctive treatment after surgery, pituitary radiotherapy, or both

Metyrapone, ke...

Teaching regarding diet and monitoring daily weight, early treatment of infections, emotional lability

National Adrenal Disease Foundation. Great Neck, NY 11021; 519-407-4...

E24.9 Cushing’s syndrome, unspecified

E24.0 Pituitary-dependent Cushing’s disease

E24.2 Drug-induced Cushing’s syndrome

E24.8 Other Cushing’s syndrome

E24.4 Alcohol-induced pseudo-Cushing’s syn...

Cushing disease is due to excessive ACTH secretion from a pituitary tumor, resulting in corticosteroid excess.

Cushing syndrome is due to excessive corticosteroid exposure from exogenou...