Skip to main content

Squamous Cell Carcinoma, Cutaneous

Reviewed 06/2018
 


BASICS

  • Squamous cell carcinoma (SCC) is a malignant epithelial tumor arising from epidermal keratinocytes. Cutaneous (nonmucous membrane) SCC is the second most common form of skin cancer.

  • Lesions most...

DIAGNOSIS

PHYSICAL EXAM

Lesions occur chiefly on chronically sun-exposed areas. 
  • Face and backs of the forearms and hands

  • Bald areas of the scalp and top of ears in men

  • The sun-exposed “V” of the neck as ...

TREATMENT

MEDICATION

First Line

  • Total excision: preferred method for SCCs, permitting histologic diagnosis of the tumor margins

  • Electrodesiccation and curettage (ED&C)

    • Best for small lesions (genera...

ONGOING CARE

FOLLOW UP RECOMMENDATIONS

Patient Monitoring

Skin exam every month for 3 months, 6 months after treatment, and then yearly 

PATIENT EDUCATION

Skin self-exam: Encourage sun-avoidance technique...

REFERENCES

1
Brantsch KD, Meisner C, Schönfisch B, et al. Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study. Lancet Oncol.  2008;9(8):713–720...

ADDITIONAL READING

  • Martorell-Calatayud A, Sanmartín Jimenez O, Cruz Mojarrieta J, et al. Cutaneous squamous cell carcinoma: defining the high-risk variant [in Spanish]. Actas Dermosifiliogr.  201...

CODES

ICD10

  • C44.92 Squamous cell carcinoma of skin, unspecified

  • C44.320 Squamous cell carcinoma of skin of unspecified parts of face

  • C44.42 Squamous cell carcinoma of skin of scalp and neck

  • C44.621 Squamo...

CLINICAL PEARLS

  • SCCs that develop from actinic keratoses are generally unaggressive.

  • Solid organ transplant patients have a 65-fold increased risk of SCC relative to the general population.

  • Unlike most ...

Subscribe to Access Full Content

Sign Up for a 10-Day Free Trial

Sign up for a 10-day FREE Trial now and receive full access to all content.

 
×