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Squamous Cell Carcinoma, Cutaneous

Reviewed 06/2019
 


BASICS

DESCRIPTION

Cutaneous squamous cell cancer is a type of cancer that is very common. It is associated with some hereditary disorders like xeroderma pigmentosum, oculocutaneous albinism, epidermod...

DIAGNOSIS

PHYSICAL EXAM

  • Lesions occur mainly on chronically exposed areas:

    • Face (especially lips, ear, nose, cheek, and eyelid) (1)

  • Lesions occur chiefly on chronically sun-exposed areas.

    • Face and backs o...

TREATMENT

MEDICATION

First Line

  • First-line treatment for cutaneous SCC is complete surgical excision with histopathologic control of excision margins.

  • Surgical excision provides these benefits (4):

    • Shorte...

ONGOING CARE

PROGNOSIS

  • Patients with high-risk cutaneous squamous cell cancer have increased risk of recurrence, lymph node, or distant metastases (4).

  • From the lesions at risk, 7–80% will locally recur...

REFERENCES

1
Simonacci F, Bertozzi N, Grieco MP, et al. Surgical therapy of cutaneous squamous cell carcinoma: our experience. Acta Biomed.  2018;89(2):242–248. [View Abstract on OvidMedline]
2
Gree...

CODES

ICD10

  • C44.92 Squamous cell carcinoma of skin, unspecified

  • C44.320 Squamous cell carcinoma of skin of unspecified parts of face

  • C44.42 Squamous cell carcinoma of skin of scalp and neck

  • C44.621 Squamo...

CLINICAL PEARLS

  • Cutaneous SCC associated with UV light exposure and immunosuppression

  • Head and neck are the most common regions for invasive cutaneous SCC.

  • MMS provides cure rates of 97% for primary cut...

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