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Squamous Cell Carcinoma, Cutaneous

Sujitha Yadlapati, MD Reviewed 04/2024
 


BASICS

DESCRIPTION

Cutaneous squamous cell cancer (SCC) is the second most common nonmelanoma skin cancer after basal cell carcinoma. 

EPIDEMIOLOGY

Nonmelanoma skin cancer is the most common malignancy w...

DIAGNOSIS

  • Histopathology remains the gold standard for the diagnosis of SCC. A punch or shave biopsy can be used to obtain a sample  (1).

  • Dermoscopy is a non-invasive technique that can help improve di...

TREATMENT

Selecting the most appropriate treatment options should involve consideration of the following: 
  • Tumor location and characteristics

  • High-risk areas

  • Recurrence rate

  • Patient expectations

  • Patient's ...

ONGOING CARE

PROGNOSIS

  • Patients with high-risk cutaneous squamous cell cancer have an increased risk of recurrence, lymph node, or distant metastases.

  • From the lesions at risk, 7–80% will locally recur ...

REFERENCES

1
Combalia A, Carrera C. Squamous Cell Carcinoma: An Update on Diagnosis and Treatment. Dermatol Pract Concept. 2020;10(3):e2020066.
2
Que SKT, Zwald FO, Schmults CD. Cutaneous squamous cell c...

CODES

ICD10

  • C44.92 Squamous cell carcinoma of skin, unspecified

  • C44.320 Squamous cell carcinoma of skin of unspecified parts of face

  • C44.42 Squamous cell carcinoma of skin of scalp and neck

  • C44.621 Squamo...

CLINICAL PEARLS

  • Cutaneous SCC associated with UV light exposure and immunosuppression

  • The head and neck are the most common regions for invasive cutaneous SCC.

  • MMS provides cure rates of 97% for primary...

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