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General Medicine

Cutaneous T-Cell Lymphoma, Mycosis Fungoides

Bryce A Ringwald, MD and Emily Ann Gorman, DO Reviewed 05/2023
 


BASICS

Cutaneous T-cell lymphoma (CTCL) is a rare group of non-Hodgkin lymphoma characterized primarily by localization of malignant T lymphocytes to the skin, less commonly it will progress to lymph ...

DIAGNOSIS

  • Diagnosis based on clinical, histopathologic, molecular biologic, and immunopathologic categories (1)

  • Clinical criteria: persistent or progressive patches and plaques lesions in a non–sun-ex...

TREATMENT

MEDICATION

Treatment must be individualized and usually involves skin-directed therapy with or without systemic therapy. No universally accepted standard approach exists to treat this disease...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Must be individualized

    • Routine physical exam with labs (CBC with Sézary cells) and imaging

PATIENT EDUCATION

  • American Academy of De...

REFERENCES

1
Jawed S, Myskowski P, Horwitz S, et al. Primary cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecula...

ADDITIONAL READING

Olsen EA, Whittaker S, Willemze R, et al. Primary cutaneous lymphoma: recommendations for clinical trial design and staging update from the ISCL, USCLC, and EORTC. ...

CODES

ICD10

  • C84.00 Mycosis fungoides, unspecified site

  • C84.08 Mycosis fungoides, lymph nodes of multiple sites

  • C84.09 Mycosis fungoides, extranodal and solid organ sites

  • C84.01 Mycosis fungoides, lymph no...

CLINICAL PEARLS

  • CTCL is a rare and typically indolent mature T-cell lymphoma presenting primarily in the skin; infiltration of activated and malignant T cells in the skin

  • MF, the most common subtype of...

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Related Images
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Mycosis fungoides with atypical small lymphocytes having convoluted, "cerebriform" nuclei.

 

Mycosis fungoides with atypical small lymphocytes having convoluted, "cerebriform" nuclei.

 

<bold>FIGURE 24-88. Mycosis fungoides.</bold> <bold>A.</bold> A 66-year-old woman presented with a 30-year history of erythematous scaly patches and plaques with telangiectases, atrophy, and pigmentation. <bold>B.</bold>The papillary dermis is expanded by an infiltrate of atypical lymphocytes. Lymphocytes with hyperchromatic nuclei infiltrate the thickened epidermis.

 

<bold>FIGURE 24-88. Mycosis fungoides.</bold> <bold>A.</bold> A 66-year-old woman presented with a 30-year history ...

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