Although most cytomegalovirus (CMV) infections are asymptomatic or cause mild disease, dis...
Congenital
~1% (0.2–2.2%) of newborns are congenitally infected with CMV (3).
Most infected newborns appear normal and are asymptomatic, although as many as 7–15% develop sensorineural...
Congenital disease: ganciclovir 6 mg/kg IV q12h for 6 weeks (3)[A], alternately valganciclovir 16 mg/kg PO q12h for 6 weeks if patient is >7 days old and can tolerate...
CMV urine culture at birth for all HIV-infected or exposed with annual testing in CMV seronegative/HIV+ children
Patients with CD4 counts <50 ...
Leruez-Ville M, Foulon I, Pass R, et al. Cytomegalovirus infection during pregnancy: state of the science. Am J Obstet Gynecol. 2020;223(3):330-349.
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B25.9 Cytomegaloviral disease, unspecified
P35.1 Congenital cytomegalovirus infection
B25.8 Other cytomegaloviral diseases
28944009 Cytomegalovirus infection (disorder)
59527008 Congenita...
CMV is a major cause of sensorineural hearing loss in young children.
CMV exposure is ubiquitous; up to 97% of adults have antibodies to CMV.
CMV mononucleosis syndrome has less cervical...
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<bold>FIGURE 42-2</bold> <bold>Clinical appearance and radiologic findings of infants with congenital cytomegalovirus. A.</bold> Infant with severe congenital CMV with stigmata of disease, including petechial rash, microcephaly, jaundice, and abnormal posture of upper extremities secondary to central nervous system (CNS) damage. <bold>B.</bold> Computerized tomographic image of an infant with CNS damage secondary to congenital CMV with severe periventricular calcificatio...
<bold>FIGURE 42-2</bold> <bold>Clinical appearance and radiologic findings of infants with congenital cytomegalovirus. ...
FIGURE 58.1. A: Lung tissue with characteristic "owl's-eye" cytomegalovirus nuclear inclusion and cytoplasmic inclusions (H&E, 31,000, oil). B: Esophageal tissue with herpes virus intranuclear inclusions with multinucleation (H&E, 31,000, oil). C: Lung tissue with a "smudged" intranuclear inclusion characteristic of adenovirus (center H&E, 31,000, oil). D: Heart tissue with an intramyocardial Toxoplasma cyst (H3E, 31,000, oil).(continued)
FIGURE 58.1. A: Lung tissue with characteristic "owl's-eye" cytomegalovirus nuclear inclusion and cytoplasmic inclusions (H&E, 31,...
An infant with congenital cytomegalovirus infection. Infant had jaundice, hepatosplenomegaly, and petechiae.
Congenital CMV "blueberry muffin" baby with jaundice and thrombocytopenia purpura.