Skip to main content

Cytomegalovirus (CMV) Inclusion Disease

David L. Lee, MD, Munima Nasir, MD and Jarrett Keller Sell, MD FAAFP AAHIVS Reviewed 06/2021
 


BASICS

Ubiquitous and common infection impacting all ages, ethnic, socioeconomic groups, and geographic areas 
  • Although most cytomegalovirus (CMV) infections are asymptomatic or cause mild disease, dis...

DIAGNOSIS

HISTORY

  • Congenital

    • ~1% (0.2–2.2%) of newborns are congenitally infected with CMV (3).

    • Most infected newborns appear normal and are asymptomatic, although as many as 7–15% develop sensorineural...

TREATMENT

MEDICATION

First Line

  • Congenital disease: ganciclovir 6 mg/kg IV q12h for 6 weeks (3)[A], alternately valganciclovir 16 mg/kg PO q12h for 6 weeks if patient is >7 days old and can tolerate...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • CMV urine culture at birth for all HIV-infected or exposed with annual testing in CMV seronegative/HIV+ children

  • Patients with CD4 counts <50 ...

REFERENCES

1
Gugliesi F, Coscia A, Griffante G, et al. Where do we stand after decades of studying human cytomegalovirus? Microorganisms. 2020;May8;8(5):685.
2
Razonable  RR. Mana...

ADDITIONAL READING

  • Leruez-Ville M, Foulon I, Pass R, et al. Cytomegalovirus infection during pregnancy: state of the science. Am J Obstet Gynecol. 2020;223(3):330-349.

  • ...

CODES

ICD10

  • B25.9 Cytomegaloviral disease, unspecified

  • P35.1 Congenital cytomegalovirus infection

  • B25.8 Other cytomegaloviral diseases

SNOMED

  • 28944009 Cytomegalovirus infection (disorder)

  • 59527008 Congenita...

CLINICAL PEARLS

  • CMV is a major cause of sensorineural hearing loss in young children.

  • CMV exposure is ubiquitous; up to 97% of adults have antibodies to CMV.

  • CMV mononucleosis syndrome has less cervical...

Subscribe to Access Full Content

Sign Up for a 10-Day Free Trial

Sign up for a 10-day FREE Trial now and receive full access to all content.

 
×