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Dengue Fever

Alexander D. Schloe, MD, Robert L. Ashley, MD and Erik R. Clauson, DO Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Dengue fever or “breakbone fever” is caused by an arbovirus—dengue virus (DENV)—a Flavivirus, from the Flaviviridae family.

  • Single-stranded positive RNA virus with four antigenically ...

DIAGNOSIS

HISTORY

  • Symptoms begin 2 to 7 days after a 4- to 7-day incubation.

  • Dengue fever presents with

    • High fever (>38.5°C—may be biphasic)

    • Headache

    • Cough, sore throat, and nasal congestion

    • Relative b...

TREATMENT

GENERAL MEASURES

  • No direct antiviral therapy available

  • Supportive care with bed rest, hydration, pain, and fever control are mainstays of treatment (4)[A].

MEDICATION

First Line

  • Volume resuscitat...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Refer all patients to an infectious disease specialist. Dengue is reportable to the CDC: 800-CDC-INFO. 

PATIENT EDUCATION

  • Dengue prevention, as well as signs and sy...

REFERENCES

1
Bhatt S, Gething PW, Brady OJ, et. al. The global distribution and burden of dengue. Nature.  2013;496(7446):504–507. [View Abstract on OvidMedline]
2
Simmons CP, Farrar JJ, Nguyen vV, ...

ADDITIONAL READING

CODES

ICD10

  • A90 Dengue fever [classical dengue]

  • A91 Dengue hemorrhagic fever

ICD9

  • 061 Dengue

  • 065.4 Mosquito-borne hemorrhagic fever

SNOMED

  • 38362002 Dengue (disorder)

  • 20927009 Dengue hemorrhagic fever (disorde...

CLINICAL PEARLS

  • Mosquito control is the most effective approach to dengue prevention.

  • Treatment requires active intravascular volume repletion to prevent or reverse hypovolemic shock.

  • Aspirin or NSAIDs ...

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