Major depressive disorder (MDD) that has failed to respond to ≥2 adequate trials of antidepressant therapy in ≥2 different classes is considered to be "Treatment Resistant."
Individua...
Symptoms are the same as in MDD. However, patients do not respond to standard form of treatment.
Important to screen for suicidality in treatment-resistant depression
Screening with SIG...
Antidepressants in combination
Citalopram (start 20 mg/day; max dos...
Frequent visits (i.e., every month)
During follow-up, evaluate side effects, dosage, and effectiveness of medication as well as need for referral to ECT or Ketamin...
F32.9 Major depressive disorder, single episode, unspecified
F33.9 Major depressive disorder, recurrent, unspecified
35489007 Depressive disorder (disorder)
66344007 Recurrent major depr...
Treatment-resistant depression is common, affecting 1/3 of those with MDD.
Combination and augmentation strategies with antidepressants, antipsychotics, therapy, and mood stabilizers ca...
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