Dermatitis herpetiformis (DH) presents as a chronic, relapsing, polymorphous, intensely pruritic, erythematous papulovesicular eruption with symmetrical distribution primarily involv...
GFD is the mainstay of treatment in DH and can lead to complete resolution of symptoms (1),(2)[A].
Typically requires 18 to 24 months of strict adherence to GFD prior to reso...
Every 6 to 12 months by physician and dietitian to evaluate GFD adherence and recurrence of symptoms
Adherence to GFD can be monitored with serol...
Bolotin D, Petronic-Rosic V. Dermatitis herpetiformis. Part I. Epidemiology, pathogenesis, and clinical presentation. J Am Acad...
Celiac Disease
Algorithm: Rash
DH is a chronic, relapsing, intensely pruritic rash that often presents with erosions, excoriations, lichenification, and pigmentary changes secondary to scratching and healing of old ...
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<bold>Figure 37.3</bold> A child with celiac disease. Notice the protruding abdomen and wasted buttocks.
dermatitis herpetiformis
Dermatitis herpetiformis. A. Pruritic, symmetric, grouped vesicles on an erythematous base are seen on the elbows and knees. B. Dermal papillary abscesses of neutrophils with vesicle formation at the dermal–epidermal junction are characteristic. C. Direct immunofluorescence reveals IgA deposited in dermal papillae in association with (but not necessarily directly upon) anchoring fibrils and elastic tissue fibers. This is the site of neutrophil infiltration and subepidermal vesicle formation.
(Courtesy W. Witmer) Elder AD, Elenitsas R, Johnson BL, et al: Synopsis and Atlas of Lever's Histopathology of the Skin. Lippincott Williams & Wilkins, Philadelphia, 1999, p 2, clin. fig. IA1; p 163�
Dermatitis herpetiformis. A. Pruritic, symmetric, grouped vesicles on an erythematous base are seen on the elbows and knees. B. Dermal papi...
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Villous atrophy with a flat surface, elongation of the crypts, and chronic inflammation of the lamina propria are characteristic of long-standing disease.
Villous atrophy with a flat surface, elongation of the crypts, and chronic inflammation of the lamina propria are characteristic of long-s...
A higher-power view shows damaged, cuboidal surface epithelium with numerous intraepithelial lymphocytes. The lamina propria is heavily infiltrated by plasma cells.
A higher-power view shows damaged, cuboidal surface epithelium with numerous intraepithelial lymphocytes. The lamina propria is heavily in...