Skip to main content

Diabetic Polyneuropathy

Samir Malkani, MRCP (UK), MD Reviewed 05/2023
 


BASICS

DESCRIPTION

Peripheral nerve dysfunction seen in diabetes; several patterns described: 
  • Symmetric polyneuropathy

    • Distal sensory or sensorimotor

  • Mononeuropathy, radiculopathy, and polyradiculopathy

    • C...

DIAGNOSIS

HISTORY

  • Most common form (typical): symmetric distal sensory or sensorimotor polyneuropathy

    • Distressing numbness, tingling, pain of legs/feet, usually worse at night; allodynia; hyperalgesia

    • Of...

TREATMENT

GENERAL MEASURES

  • Maintain blood glucose control.

  • Provide appropriate footwear to prevent pressure damage to insensate feet.

MEDICATION

Specific treatment to reverse nerve damage, other than impr...

ONGOING CARE

PROGNOSIS

  • Generalized symmetric polyneuropathies

    • Usually slow, chronic progression

    • Insensitive but painless foot as pain lessens

  • Focal neuropathies

    • Recovery over months to years

COMPLICATIONS

  • Cl...

REFERENCES

1
Pop-Busui R, Ang L, Boulton AJM, et al. Diagnosis and Treatment of Painful Diabetic Peripheral Neuropathy. Arlington, VA: American Diabetes Association, 2022. doi: 10.2337/db2022-01.
2
Liamp...

ADDITIONAL READING

  • Jensen TS, Karlsson P, Gylfadottir SS, et al. Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management. Brain. 2021;144:1...

SEE ALSO

Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 

CODES

ICD10

  • E10.42 Type 1 diabetes mellitus with diabetic polyneuropathy

  • E11.42 Type 2 diabetes mellitus with diabetic polyneuropathy

  • E13.42 Oth diabetes mellitus with diabetic polyneuropathy

  • E08.42 Diabe...

CLINICAL PEARLS

  • Occasionally, when glycemic control improves dramatically, as can occur when treatment for diabetes is initiated, there may be a worsening of neuropathy symptoms (described as treatmen...

Subscribe to Access Full Content

Sign Up for a 10-Day Free Trial

Sign up for a 10-day FREE Trial now and receive full access to all content.

 
×