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Diphtheria

Navpreet K. Singh, MD Reviewed 05/2023
 


BASICS

DESCRIPTION

  • Acute respiratory tract infection typically presenting as a membranous pharyngitis, caused by the gram-positive facultative anaerobic bacterium Corynebacterium diphtheriae

  • Greek name ...

DIAGNOSIS

HISTORY

  • Membranous pharyngotonsillar diphtheria

    • Sore throat

    • Malaise, fever, and prostration

  • Nasal diphtheria

    • Rhinorrhea (often unilateral)

    • Often chronic, mild course

  • Obstructive laryngotracheitis

    • Ho...

TREATMENT

GENERAL MEASURES

  • Appropriate health care generally entails:

    • Consider admission to monitor cardiac and respiratory status (must act on presumptive diagnosis because therapy cannot wait for cult...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Rest for at least 3 weeks until risk of developing myocarditis has passed. 

Patient Monitoring

  • ECG, cardiac enzymes, neurologic status, and respiratory status; seri...

REFERENCES

1
Sharma NC, Efstratiou A, Mokrousov I, et al. Diphtheria. Nat Rev Dis Primers. 2019 Dec 5;5(1):81.
2
Ramamurthy  T, Azim  S, Ganguly  S, et al. Diphtheria: an emerging...

ADDITIONAL READING

Habib H, Kurniawaty H. Triage in the Time of Diphtheria. West J Emerg Med. 2020 Aug 21;21(5):1156-1159.  

CODES

ICD10

  • A36.2 Laryngeal diphtheria

  • A36.3 Cutaneous diphtheria

  • A36.89 Other diphtheritic complications

  • A36.85 Diphtheritic cystitis

  • A36.83 Diphtheritic polyneuritis

  • A36.9 Diphtheria, unspecified

  • A36.84 Di...

CLINICAL PEARLS

  • Culture, check immunization status, and consider antimicrobial prophylaxis (penicillin or erythromycin) for close contacts of known cases of C. diphtheriae.

  • Tdap is recommended between ...

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