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Disseminated Intravascular Coagulation

Jan Cerny, PhD, MD and Alice Kennedy, BS Reviewed 06/2022
 


BASICS

DESCRIPTION

  • Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by diffuse activation of intravascular coagulation and fibrinolysis, often as a response to a syste...

DIAGNOSIS

  • Symptoms and signs are related to the underlying disease process and DIC. Abnormal bleeding or thromboses in patients with conditions associated with DIC should prompt consideration for a di...

TREATMENT

Heterogeneity of the underlying disorders and the clinical presentations makes the therapeutic approach to DIC difficult: 
  • Treat underlying condition (e.g., evacuation of uterus in abruptio p...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Monitor closely until much improved.

  • Serial platelet count, coagulation tests, and fibrinogen levels to see effect of therapeutic interventions

  • Re...

REFERENCES

1
Gando  S, Levi  M, Toh  CH. Disseminated intravascular coagulation. Nat Rev Dis Primers.  2016; 2:16037. [View Abstract on OvidMedline]
2
Alh...

CODES

ICD10

  • D65 Disseminated intravascular coagulation [defibrination syndrome]

SNOMED

  • 67406007 Disseminated intravascular coagulation

  • 34417008 Disseminated intravascular coagulation in newborn

CLINICAL PEARLS

  • DIC is an acquired syndrome characterized by diffuse activation of intravascular coagulation and fibrinolysis that can lead to end organ dysfunction and increased mortality

  • Clinical pre...

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