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Disseminated Intravascular Coagulation

Jan Cerny, PhD, MD Reviewed 04/2024
 


BASICS

DESCRIPTION

  • Disseminated intravascular coagulation (DIC) is an acquired, life-threatening syndrome affecting the coagulation system characterized by diffuse activation of clotting factors and fi...

DIAGNOSIS

  • Symptoms and signs are related to the underlying disease process and DIC. Abnormal bleeding or thromboses in patients with conditions associated with DIC should prompt consideration for the ...

TREATMENT

Heterogeneity of the underlying disorders and the clinical presentations makes the therapeutic approach to DIC complex: 
  • Treat underlying condition (e.g., evacuation of uterus in abruptio pla...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Monitor closely until much improved.

  • Serial platelet count, coagulation tests, and fibrinogen levels to evaluate therapeutic interventions

  • Repeate...

REFERENCES

1
Adelborg K, Larsen JB, Hvas AM. Disseminated intravascular coagulation: epidemiology, biomarkers, and management. British Journal of Haematology. 2021;192(5):803-818. doi:10.1111/bjh.17172...

CODES

ICD10

  • D65 Disseminated intravascular coagulation [defibrination syndrome]

SNOMED

  • 67406007 Disseminated intravascular coagulation

  • 34417008 Disseminated intravascular coagulation in newborn

CLINICAL PEARLS

  • DIC is an acquired syndrome characterized by diffuse activation of intravascular coagulation and fibrinolysis that can lead to end organ dysfunction and increased mortality

  • Clinical pre...

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