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Disseminated Intravascular Coagulation

Jan Cerny, MD, PhD and Xin Wang, MD Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by diffuse activation of intravascular coagulation. It can originate from and cause damage to the m...

DIAGNOSIS

Symptoms and signs are related to the underlying disease process and DIC. 

HISTORY

DIC can present at any point in the spectrum between bleeding and thrombosis in the right clinical setting. L...

TREATMENT

Heterogeneity of the underlying disorders and the clinical presentations makes the therapeutic approach to DIC difficult: 
  • Treat underlying condition (e.g., evacuation of uterus in abruptio p...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Monitor closely until much improved.

  • Serial platelet count, coagulation tests, and fibrinogen levels to see effect of therapeutic interventions

  • Re...

REFERENCES

1
Gando S, Levi M, Toh CH. Disseminated intravascular coagulation. Nat Rev Dis Primers.  2016; 2:16037. [View Abstract on OvidMedline]
2
Boral BM, Williams DJ, Boral Ll. Disseminated intr...

ADDITIONAL READING

  • Gando S, Meziani F, Levi M. What’s new in the diagnostic criteria of disseminated intravascular coagulation? Intensive Care Med.  2016;42(6):1062–1064. [View Abstract on OvidMe...

CODES

ICD10

  • D65 Disseminated intravascular coagulation

  • P60 Disseminated intravascular coagulation of newborn

ICD9

  • 286.6 Defibrination syndrome

  • 776.2 Disseminated intravascular coagulation in newborn

SNOMED

  • 6...

CLINICAL PEARLS

  • DIC is an acquired syndrome characterized by diffuse activation of intravascular coagulation. It can originate from and cause damage to the microvasculature, which, if sufficiently sev...

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