Disseminated Intravascular Coagulation

Jan Cerny, MD, PhD and Xin Wang, MD Reviewed 06/2019

BASICS

Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by diffuse activation of intravascular coagulation. It can originate from and cause damage to the m...

Symptoms and signs are related to the underlying disease process and DIC.

DIC can present at any point in the spectrum between bleeding and thrombosis in the right clinical setting. L...

Heterogeneity of the underlying disorders and the clinical presentations makes the therapeutic approach to DIC difficult:

Monitor closely until much improved.
Serial platelet count, coagulation tests, and fibrinogen levels to see effect of therapeutic interventions
Re...

Gando S, Levi M, Toh CH. Disseminated intravascular coagulation. Nat Rev Dis Primers. 2016; 2:16037. [View Abstract on OvidMedline]

Boral BM, Williams DJ, Boral Ll. Disseminated intr...

Gando S, Meziani F, Levi M. What’s new in the diagnostic criteria of disseminated intravascular coagulation? Intensive Care Med. 2016;42(6):1062–1064. [View Abstract on OvidMe...

DIC is an acquired syndrome characterized by diffuse activation of intravascular coagulation. It can originate from and cause damage to the microvasculature, which, if sufficiently sev...

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