Disseminated Intravascular Coagulation

Jan Cerny, MD, PhD and Azra Borogovac, MD Reviewed 06/2018

BASICS

DESCRIPTION

Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by diffuse activation of intravascular coagulation. It can originate from and cause damage to the m...

DIAGNOSIS

Symptoms and signs are related to the underlying disease process and DIC.

HISTORY

Symptoms of microvascular thrombosis (e.g., renal failure, hepatic and neurologic dysfunctions) as well as di...

TREATMENT

Heterogeneity of the underlying disorders and the clinical presentations makes the therapeutic approach to DIC difficult:

Treat underlying condition (e.g., evacuation of uterus in abruptio p...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

Monitor closely until much improved.
Serial platelet count, coagulation tests, and fibrinogen levels to see effect of therapeutic interventions

PROGNOSIS

REFERENCES

Singh B, Hanson AC, Alhurani R, et al. Trends in the incidence and outcomes of disseminated intravascular coagulation in critically ill patients (2004–2010): a population-based study. Ches...

ADDITIONAL READING

Squizzato A, Hunt BJ, Kinasewitz GT, et al. Supportive management strategies for disseminated intravascular coagulation. An international consensus. Thromb Haemost. 2016;115(5...

CODES

ICD10

D65 Disseminated intravascular coagulation
P60 Disseminated intravascular coagulation of newborn

ICD9

286.6 Defibrination syndrome
776.2 Disseminated intravascular coagulation in newborn

SNOMED

6...

CLINICAL PEARLS

DIC is an acquired syndrome characterized by diffuse activation of intravascular coagulation. It can originate from and cause damage to the microvasculature, which, if sufficiently sev...

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