Epstein-Barr virus (EBV) is a member of the herpes virus family; human herpes virus 4.
Two subtypes: ST1 predominates in Western Hemisphere, Southeast Asia; ST1 and ST2 equally preval...
May be either abrupt or insidious in onset
Syndrome of fatigue, malaise, and sore throat
In adults, temperature may rise to 103°F (39.4°C) and gradually fall over a variable period of 7...
Treatment is primarily supportive.
NSAIDs or acetaminophen
During acute stage, limit activity for 4 weeks to reduce potential complications (e.g., splenic rupture).
Transplant recipients who d...
Rupture of the spleen may be fatal if not recognized; it requires blood transfusions, treatment for shock, and splenectomy. Occurrence is estimated at 0.1%.
Arai A. Chronic Active Epstein-Barr Virus Infection: The Elucidation of the Pathophysiology and the Development of Therapeutic Methods. Microorgan...
B27.00 Gammaherpesviral mononucleosis without complication
B27.09 Gammaherpesviral mononucleosis with other complications
B27.01 Gammaherpesviral mononucleosis with polyneuropathy
B27.02 Gamma...
98% of patients with acute IM present with some combination of fever, sore throat, cervical node enlargement, and tonsillar hypertrophy.
False-negative monospot (heterophile antibody) i...
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Infectious Mononucleosis White cells Agranulocytosis Proliferation of lymphocytes (12-25 X 10 9 /L) Greater than 20% reactive lymphocytes Immunoblasts may be present Plasmacytoid lymphocytes may be present Red cells May have an autoimmune hemolytic anemia Platelets Normal to decreased Serological tests Paul-Bunnell heterophile antibodies positive Peripheral Smear
Infectious Mononucleosis White cells Agranulocytosis Proliferation of lymphocytes (12-25 X 10 9 /L) Greater than 20% reactive lymp...
infectious mononucleosis
<bold><italic>Figure 11-12</bold> The blood in infectious mononucleosis.</bold> The large "atypical" lymphocyte is characteristic.
<bold><italic>Figure 11-12</bold> The blood in infectious mononucleosis.</bold> The large "atypical" lymphocyte is...
<bold>FIGURE 20-50. Infectious mononucleosis.</bold> Atypical lymphocytes are characteristic.
Eruption occurring in a young man who received amoxicillin just prior to mononucleosis diagnosis
Close-up of previous patient
<bold>Figure 40.11</bold> Tonsils of an adolescent who has infectious mononucleosis; note the red enlarged tonsils with the thick white covering.
<bold>Figure 40.11</bold> Tonsils of an adolescent who has infectious mononucleosis; note the red enlarged tonsils with the t...
FIG. 11.55. Pharyngitis in infectious mononucleosis. This girl has inflamed, bilaterally swollen tonsils with a diffuse exudate, as is often seen with infectious mononucleosis.
FIG. 11.55. Pharyngitis in infectious mononucleosis. This girl has inflamed, bilaterally swollen tonsils with a diffuse exudate, as is oft...
Role of Epstein-Barr virus (EBV) in infectious mononucleosis, nasopharyngeal carcinoma, and Burkitt lymphoma. EBV invades and replicates within the salivary glands or pharyngeal epithelium, and is shed into the saliva and respiratory secretions. In some people, the virus transforms pharyngeal epithelial cells, leading to nasopharyngeal carcinoma. In people who are not immune from childhood exposure, EBV causes infectious mononucleosis. EBV infects B lymphocytes, which undergo polyclonal act...
Role of Epstein-Barr virus (EBV) in infectious mononucleosis, nasopharyngeal carcinoma, and Burkitt lymphoma. EBV invades and replicates w...