Erythema multiforme (EM) is relatively common, acute, recurrent, self-limiting inflammatory disease.
Mostly (~90% of cases) triggered by infectious agents (up to 50% by herpes simplex virus [H...
Absent or mild prodromal symptoms
Acute, self-limiting, episodic course
History of new medication
Preceding HSV infection 10 to 15 days before the skin eruptions
Rash involving t...
Step 1: Discontinue or treat inciting factor (1).
Wound care for severe cases with epidermal detachment
Oral lesions should be addressed to insure maintenance of PO intake. Thi...
The disease is self-limiting.
Complications are rare, with no mortality.
Sola CA, Beute TC. Erythema multiforme. J Spec Oper Med. 2014;14(3):90–92. [View Abstract on OvidMedline]
Wetter DA, Davis MD. Recurrent erythema multiforme: clinical characte...
L51.9 Erythema multiforme, unspecified
L51.8 Other erythema multiforme
L51.0 Nonbullous erythema multiforme
695.10 Erythema multiforme, unspecified
695.11 Erythema multiforme minor
EM is diagnosed clinically by careful review of the history, thorough detailed physical exam, and by excluding other similar disorders. No lab tests are required for the diagnosis.
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