A delayed-type hypersensitivity reaction to various antigens, or an autoimmune reaction presenting as a panniculitis (1) that affects subcutaneous fat
Clinical pattern of multiple, bi...
Often a prodrome 1 to 3 weeks prior to onset of lesions; can consist of malaise, fever, weight loss, cough, and arthralgia
Increasingly tender nodules on the legs, usually over the shi...
Condition usually self-limited within 1 to 2 months
All medications listed as treatment for EN are off-label uses of the medications. There are no specific FDA-approved medications.
Keep legs elevated.
Elastic wraps or support stockings may be helpful when patients are ambulating.
Bartyik K, Várkonyi A, Kirschner A, et al. Erythema nodosum in association with celiac disease. Pediatr Dermatol. 2004;21(3):227–230. [View Abstract on OvidMedline]
Chong TA, ...
L52 Erythema nodosum
A18.4 Tuberculosis of skin and subcutaneous tissue
695.2 Erythema nodosum
017.10 Erythema nodosum with hypersensitivity reaction in tuberculosis, unspecified
Lesions of EN appear to be erythematous patches, but when palpated, their underlying nodularity is appreciated.
Evaluation for a concerning underlying etiology is necessary in EN, but m...
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