A delayed-type hypersensitivity reaction to various antigens, or an autoimmune reaction presenting as a panniculitis (1) that affects subcutaneous fat
Clinical pattern of multiple, b...
Often a prodrome 1 to 3 weeks prior to onset of lesions; can consist of malaise, fever, weight loss, cough, and arthralgia
Increasingly tender nodules on the legs, usually over the shi...
Condition usually self-limited within 1 to 2 months
All medications listed as treatment for EN are off-label uses of the medications. There are no specific FDA-approved medications.
Keep legs elevated.
Elastic wraps or support stockings may be helpful when patients are ambulating.
Bartyik K, Várkonyi A, Kirschner A, et al. Erythema nodosum in association with celiac disease. Pediatr Dermatol. 2004;21(3):227–230. [View Abstr...
L52 Erythema nodosum
A18.4 Tuberculosis of skin and subcutaneous tissue
32861005 Erythema nodosum (disorder)
74610006 Tuberculous erythema nodosum (disorder)
402969008 Erythema nodosum du...
Lesions of EN appear to be erythematous patches, but when palpated, their underlying nodularity is appreciated.
Evaluation for a concerning underlying etiology is necessary in EN, but m...
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Erythema nodosum
Figure 158.15. Typical cutaneous lesions of erythema nodosum leprosum.
Erythema nodosum.
Dale Berg, Katherine Worzala, Atlas of Adult Physical Diagnosis. Philadelphia: Lippincott Williams & Wilkins, 2006.
Erythema nodosum. These tender nodules occurred during pregnancy and resolved postpartum. From Goodheart HP. Goodheart's Photoguide to Common Skin Disorders: Diagnosis and Management, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins, 2009.
Erythema nodosum. These tender nodules occurred during pregnancy and resolved postpartum. From Goodheart HP. Goodheart's Photoguide to Comm...
Erythema nodosum. Acute red, tender nodules appeared in this patient after she began taking oral contraceptives. From Goodheart HP. Goodheart's Photoguide to Common Skin Disorders: Diagnosis and Management, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins, 2009.
Erythema nodosum. Acute red, tender nodules appeared in this patient after she began taking oral contraceptives. From Goodheart HP. Goodhea...
Erythema nodosum. These are healing “contusiform” lesions. From Goodheart HP. Goodheart's Photoguide to Common Skin Disorders: Diagnosis and Management, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins, 2009.
Erythema nodosum. These are healing “contusiform” lesions. From Goodheart HP. Goodheart's Photoguide to Common Skin Disorders: Diagnosis an...
FIG. 6.9. Erythema nodosum. This teenager has the typical erythematous and nodular lesions of erythema nodosum along his anterior tibia. Palpation accentuates appreciation of the nodularity and elicits tenderness. Evaluation of this boy was positive only for streptococcal pharyngitis.
FIG. 6.9. Erythema nodosum. This teenager has the typical erythematous and nodular lesions of erythema nodosum along his anterior tibia. Pa...