Hemolytic anemia of the fetus or newborn is caused by transplacental transmission of maternal IgG antibodies against fetal red blood cells.
When severe, fetal anemia may result in ext...
Antenatal (the fetus)
Hepatomegaly
Splenomegaly
Hydrops (two or more of the following ultrasonography [US] findings: ascites, pericardial effusion, pleural effusion, skin edema, po...
Intrauterine transfusion is indicated when the fetal hematocrit is ≤30 OR is two standard deviations below the mean value for gestational age.
The intravascular approach for t...
50% of affected infants have mild disease and require no treatment (or treatment of anemia and jaundice only after delivery).
30% have moderate disease with anemia and hepatomegal...
Bowman J. Thirty-five years of Rh prophylaxis. Transfusion. 2003;43(12):1661–1666.
Cardo L, García BP, Alvarez FV. Non-invasive fetal RHD genotyping in the first trimester of p...
Anemia, Autoimmune Hemolytic
Algorithm: Jaundice, Newborn
P55.9 Hemolytic disease of newborn, unspecified
P55.0 Rh isoimmunization of newborn
P55.1 ABO isoimmunization of newborn
P55.8 Other hemolytic diseases of newborn
773.2 Hemolytic disease of...
Alloimmunization is the most common cause of HDFN; Rh antigen alloimmunization is most frequently acquired via fetomaternal hemorrhage and inadequate dosing or lack of treatment with R...
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