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Factor V Leiden

Elyas Parsa, Osteopathic Doctor and Viktor Limanskiy, M.D. Reviewed 06/2022
 


BASICS

DESCRIPTION

  • Factor V Leiden is a genetic point mutation in the F5 gene at the activated protein C (APC) cleavage site on the factor V and Va molecule leading to increase in thrombin and as a res...

DIAGNOSIS

HISTORY

  • It is critical to differentiate between provoked and unprovoked VTE and determine family history, risk factors, detailed symptoms.

  • In up to 70% of patients suffering from VTE, a provok...

TREATMENT

Only indicated if with thrombotic event. For asymptomatic patients (no thrombotic event), prophylaxis is not recommended. 

GENERAL MEASURES

  • Initiation of anticoagulation therapy for acute veno...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

Warfarin use requires periodic (~monthly after initial stabilization) INR measurements, with a goal of 2 to 3. 

DIET

Large amounts of foods rich i...

REFERENCES

1
Dłuski  D, Mierzyński  R, Poniedziałek-Czajkowska  E, et al. Adverse pregnancy outcomes and inherited thrombophilia. J Perinat Med.  2018;46(4):411–417. [View ...

SEE ALSO

Deep Vein Thrombophlebitis 

CODES

ICD10

D68.51 Activated protein C resistance 

SNOMED

  • 307091009 factor V Leiden mutation (disorder)

  • 307116001 Heterozygous Factor V Leiden mutation

  • 307115002 Homozygous Factor V Leiden mutation

CLINICAL PEARLS

  • Extremely rare in Asian and African populations

  • Asymptomatic patients with factor V Leiden do not need anticoagulation.

  • For pregnant women homozygous for factor V Leiden but no prior his...

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