Skip to main content
General Medicine

Factor V Leiden

Reviewed 06/2020
 


BASICS

DESCRIPTION

  • Factor V Leiden is a genetic mutation at the activated protein C (APC) cleavage site on the factor V and Va molecule leading to the most common form of inherited thrombophilia.

  • System...

DIAGNOSIS

HISTORY

  • Previous thrombosis

  • Family history of thrombosis

PHYSICAL EXAM

  • Family history of factor V Leiden mutation

  • Findings suggestive of VTE in any form (DVT, PE, cerebral thrombosis): 10–26% of ...

TREATMENT

Only indicated if with thrombotic event 

GENERAL MEASURES

  • Like general VTE treatment, patients with factor V Leiden and a first thrombosis should be anticoagulated initially with heparin or lo...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

Warfarin use requires periodic (~monthly after initial stabilization) INR measurements, with a goal of 2 to 3 (6)[A]. 

DIET

  • No restrictions

  • Large a...

REFERENCES

1
Dłuski D, Mierzyński R, Poniedziałek-Czajkowska E, et al. Adverse pregnancy outcomes and inherited thrombophilia. J Perinat Med.  2018;46(4):411–417.
2
Rosendaal FR, Koster T, Vandenbro...

ADDITIONAL READING

Seligsohn U, Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med.  2001;344(16):1222–1231. 

SEE ALSO

Deep Vein Thrombophlebitis 

CODES

ICD10

D68.51 Activated protein C resistance 

ICD9

289.81 Primary hypercoagulable state 

SNOMED

  • 307091009 factor V Leiden mutation (disorder)

  • 307116001 Heterozygous Factor V Leiden mutation

  • 307115002 Ho...

CLINICAL PEARLS

  • Extremely rare in Asian and African populations

  • Asymptomatic patients with factor V Leiden do not need anticoagulation.

  • For pregnant women homozygous for factor V Leiden but no prior his...

Subscribe to Access Full Content

Sign Up for a 10-Day Free Trial

Sign up for a 10-day FREE Trial now and receive full access to all content.

START 10-DAY FREE TRIAL
Subscribe Now
GET CME/CE
Related Images
Left Arrow Button Right Arrow Button
Figure 16-55 IVC UMBRELLA FILTER. A. AP Lumbar. B. Lateral Lumbar. This metallic umbrella fillter is placed in the inferior vena cava to capture emboli from the lower extremities in patients with thrombophlebitis.
Figure 16-55 IVC UMBRELLA FILTER. A. AP Lumbar. B. Lateral Lumbar. This metallic umbrella fillter is placed in the inferior vena cava to ca...
Figure 18-110DEEP VENOUS THROMBOSIS. A. Ultrasound,Lower Limb.Note the thrombus within the femoral vein (arrows). Failure of the vein to collapse from the compression of the ultra sound head confirms the presence of endoluminal thrombus (arrowheads). B. Pulmonary Embolism,Pulmonary CT Angiogram, Axial Chest.Observe the emboliin the pulmonary artery (arrow) and left atrium (arrow). COMMENT:Lower limb ultrasound evaluation is routinely p...
Figure 18-110DEEP VENOUS THROMBOSIS. A. Ultrasound,Lower Limb.Note the thrombus within the femoral vein (arrows). Failure of the vein to co...
FIGURE 24-15 Common sites of venous thrombosis. (A) Superficial thrombophlebitis. (B) Most common form of deep thrombophlebitis. (C and D) Deep thrombophlebitis from the calf to iliac veins.
FIGURE 24-15 Common sites of venous thrombosis. (A) Superficial thrombophlebitis. (B) Most common form of deep thrombophlebitis. (C and D) ...
Figure 13.28. Measurement of the lower extremity circumference. Increase in size is consistent with swelling, which might be due to a deep venous thrombosis.
Figure 13.28. Measurement of the lower extremity circumference. Increase in size is consistent with swelling, which might be due to a deep ...
Schematic of development of thrombus in deep vein
Schematic of development of thrombus in deep vein
Venous thrombosis. The femoral vein has been opened to reveal a large thrombus within the lumen.
Venous thrombosis. The femoral vein has been opened to reveal a large thrombus within the lumen.
    ×
     
    ©2020 Wolters Kluwer Health, Inc. and/or its affiliates. All rights reserved.

    Enter An Access Code

     
    We are unable to redeem your access code. Please try again another time.
    Enter the code from your copy of The 5-Minute Clinical Consult or another access code to create an account.
    ×
    ×
    This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept