A spectrum of fatty liver diseases not due to excess alcohol consumption ranging from nonalcoholic fatty liver (NAFL), to nonalcoholic steatohepatitis (NASH), to cirrhosis with hepatocyte injur...
Routine screening not recommended.
Consider NAFLD in patients with asymptomatic aminotransferase elevations (1)[A].
Can occur with normal AST/ALT levels (1)[A]
NAFLD has no distinguishing histo...
Sustained weight loss (3–5% body weight) through lifestyle modification is most successful treatment (1,6)[A]. Weight loss for those who are overweight or obese is the only therapy that has ...
Annual monitoring of LFTs (1,6)[B]
Consider surveillance with US or CT scan to evaluate for disease progression (6)[B]. Improvements provide motivation for lifesty...
Oseini AM, Sanyal AJ. Therapies in non-alcoholic steatohepatitis (NASH). Liver Int. 2017;37(Suppl 1):97–103.
Spengler EK, Loomba R. Recommendations for diagnosis, referral for ...
NAFLD is a major cause of liver disease. Spectrum ranges from NAFL to NASH, advanced fibrosis, and cirrhosis.
NAFLD is the most common chronic liver disease in children; there has been ...
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Homeless diabetic man with painful foot showing gangrene and dystrophic nails
Necrobiosis lipoidica diabeticorum. Atrophic patch present x 6 mo.
Chronic hepatitis with cirrhosis. A photomicrograph of the liver from a patient with long-standing chronic active hepatitis B shows hepatocellular nodules and chronically inflamed fibrous septa.
Chronic hepatitis with cirrhosis. A photomicrograph of the liver from a patient with long-standing chronic active hepatitis B shows hepato...
Microvesicular fatty liver. A liver biopsy specimen in a case of Reye syndrome shows small droplet fat in hepatocytes and centrally located nuclei.
Microvesicular fatty liver. A liver biopsy specimen in a case of Reye syndrome shows small droplet fat in hepatocytes and centrally locate...
Alcoholic cirrhosis. The surface of the liver displays innumerable small, regular nodules.
Alcoholic cirrhosis. A photomicrograph shows small regular nodules surrounded by uniform fibrous septa.
Cirrhosis of the liver. The consequence of chronic hepatic injury is the formation of regenerating nodules separated by bands of fibrous connective tissue (blue).
Cirrhosis of the liver. The consequence of chronic hepatic injury is the formation of regenerating nodules separated by bands of fibrous co...