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Nonalcoholic Fatty Liver Disease (NAFLD)

Jill T Wei Doherty, MD, Anita Wong, MD and Daniel T. Lee, MA, MD Reviewed 06/2022
 


BASICS

  • A spectrum of fatty liver diseases ranging from nonalcoholic fatty liver (NAFL), to nonalcoholic steatohepatitis (NASH), to fibrosis and cirrhosis, not due to other cause of fatty infiltration ...

DIAGNOSIS

  • Routine screening not recommended because of lack of effective drug treatment and unclear long-term benefits of screening (2)

  • Consider NAFLD in patients with asymptomatic aminotransferase el...

TREATMENT

Emphasis on early management of metabolic risk factors, NAFLD associated with increased cardiovascular morbidity and mortality 

GENERAL MEASURES

  • Weight loss for those who are overweight or obe...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • Annual monitoring of LFTs (1)

  • Surveillance with US or CT to evaluate for disease progression every 2-3 years, or sooner if increasing metabolic risk factors.

  • Routi...

REFERENCES

1
Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver diseases...

ADDITIONAL READING

  • Kumar R, Priyadarshi RN, Anand U. Non-alcoholic Fatty Liver Disease: Growing Burden, Adverse Outcomes and Associations. J Clin Transl Hepatol. 2020;8(1):76-86. ...

SEE ALSO

Alcohol Use Disorder (AUD); Cirrhosis of the Liver; Diabetes Mellitus, Type 2; Metabolic Syndrome 

CODES

ICD10

K76.0 Fatty (change of) liver, not elsewhere classified 

SNOMED

197315008 Non-alcoholic fatty liver (disorder) 

CLINICAL PEARLS

  • NAFLD is a major cause of liver disease, and is increasing every year with increasing rates of overweight and obesity.

  • Spectrum ranges from NAFL to NASH, advanced fibrosis, and cirrhosi...

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