Classic definition
Repeated fever >38.3°C
Fever duration at least 3 weeks
Diagnosis remains uncertain (1) after 1 week of study in the hospital.
In over 50% of cases, no etiology is ...
Treatment depends on the specific etiology.
Empiric therapy is not recommended in patients with prolonged fever, because it may camouflage and therefore delay diagnosis, and s...
Cunha BA, Lortholary O, Cunha CB. Fever of unknown origin: a clinical approach. Am J Med. 2015;128(10):1138.e1–1138.e15. [View Abstract on OvidMedli...
Arteritis, Temporal; Arthritis, Juvenile Idiopathic; Colon Cancer; Cytomegalovirus (CMV) Inclusion Disease; Endocarditis, Infective; Hepatoma (Hepatocellular Carcinoma); HIV/AIDS; Lupus Eryth...
A sequential approach to FUO based on a careful history, physical examination, with targeted testing and imaging typically yields an appropriate diagnosis and avoids excessive nontarge...
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