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Fox-Fordyce Disease

Franklin J Berkey, DO and Dongsheng Jiang, MS, MD Reviewed 06/2021
 


BASICS

DESCRIPTION

A chronic pruritic skin condition involving inflammation of the apocrine glands. Named after the two physicians who first described it. Also known as apocrine duct occlusion or apocr...

DIAGNOSIS

HISTORY

  • Development of pruritic papules at the time of puberty with gradual worsening

  • Extreme pruritus.

  • Symptoms may improve with pregnancy.

  • Heat, humidity, sweating, and stress exacerbate sympt...

TREATMENT

GENERAL MEASURES

  • Nonsurgical treatment is difficult because no single treatment has been shown to be very effective.

  • Avoidance of excessive sweating or heat may ameliorate symptoms.

MEDICATION

First Line

ONGOING CARE

PATIENT EDUCATION

Avoid activities that may result in increased sweating. 

PROGNOSIS

Lesions may last months to years or may subsequently resolve with treatment. Long-term follow-up studies ...

REFERENCES

1
Shackelton J, English JC 3rd. Fox-Fordyce Disease (Apocrine Miliaria). J Pediatr Adolesc Gynecol. 2011 Jun;24(3):108-9.
2
Byth LA, Byth J. Fox-Fordyce disease: Insights from cases induced by...

CODES

ICD10

L75.2 Apocrine miliaria 

SNOMED

  • 65038009 Fox-Fordyce disease

  • 403372003 Fox-Fordyce disease of axillae

  • 403373008 Fox-Fordyce disease of vulva (disorder)

CLINICAL PEARLS

  • Fox-Fordyce presents as chronic pruritic papules in areas where sweat glands are concentrated.

  • Seen primarily in females, ages 13-35, and symptoms may improve with pregnancy

  • Pruritus may...

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