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Gilbert Syndrome

Jared Morphew, MD and Astrud San Antonio Villareal, MD Reviewed 05/2023
 


BASICS

Also known as Meulengracht disease 

DESCRIPTION

A benign, inherited syndrome in which mild, intermittent unconjugated hyperbilirubinemia occurs in the absence of hemolysis or liver dysfunction 
Pe...

DIAGNOSIS

HISTORY

  • In patients with GS, a nonpruritic jaundice can occur in the setting of stressors like fasting, dehydration, infection, lack of sleep, physical exertion or overexertion, menstruation,...

TREATMENT

  • Outpatient

  • Avoid unnecessary testing and procedures.

  • Specific treatment is not necessary.

  • Discussing mode of inheritance with patients and family members is important to prevent unnecessary tes...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

Once GS has been confidently diagnosed, no further monitoring is required. 

PATIENT EDUCATION

  • Reassure patients that GS is benign.

  • Educate patients...

REFERENCES

1
Wagner KZ, Shiels RG, Lang CA, et al. Diagnostic criteria and contributors to Gilbert’s syndrome. Crit Rev Clin Lab Sci. 2018;55(2):129-139
2
Kwo PY, Cohen SM, Lim JK. ACG Clinical Guideline...

CODES

SNOMED

  • 27503000 Gilbert’s syndrome (disorder)

  • 5655007 Inherited disorder of bilirubin metabolism

CLINICAL PEARLS

  • GS is a benign, inherited syndrome, in which mild, intermittent unconjugated hyperbilirubinemia causing jaundice occurs with otherwise normal liver function.

  • Reduced hepatic bilirubin c...

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