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Gilbert Syndrome

Alethea Y. Turner, FAAFP, DO Reviewed 06/2021
 


BASICS

DESCRIPTION

A benign, inherited syndrome in which mild, intermittent unconjugated hyperbilirubinemia occurs in the absence of hemolysis or liver dysfunction 
Pediatric Considerations

Rare for the ...

DIAGNOSIS

HISTORY

  • In patients with GS, a nonpruritic jaundice can occur in the setting of stressors like fasting, dehydration, infection, lack of sleep, physical exertion, or surgery. Other symptoms th...

TREATMENT

  • Outpatient

  • Avoid unnecessary testing and procedures.

  • Specific treatment is not necessary (1)[C].

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

Once GS has been confidently diagnosed, no further monitoring is required. 

PATIENT EDUCATION

  • Reassure patients that GS is benign.

  • Educate patients...

REFERENCES

1
Watson  KJ, Gollan  JL. Gilbert’s syndrome. Baillieres Clin Gastroenterol.  1989;3(2):337–355. [View Abstract on OvidMedline]
2
...

CODES

SNOMED

  • 27503000 Gilbert’s syndrome (disorder)

  • 5655007 Inherited disorder of bilirubin metabolism

CLINICAL PEARLS

  • GS is a benign, inherited syndrome, in which mild, intermittent unconjugated hyperbilirubinemia causing jaundice occurs with otherwise normal liver function.

  • Reduced hepatic bilirubin c...

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