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Glomerulonephritis, Postinfectious

Theodore Flaum, DO, FACOFP and Samantha Faryn Gottlieb, DO, MS Reviewed 06/2020
 


BASICS

DESCRIPTION

Postinfectious glomerulonephritis (PIGN) is an immune complex disease associated with nonrenal infection by certain strains of bacteria, most commonly Streptococcus and Staphylococcu...

DIAGNOSIS

HISTORY

  • Patients present with acute nephritic syndrome, characterized by sudden onset of hematuria associated with edema and HTN 1 to 2 weeks after an infection.

  • A triad of edema, hematuria, a...

TREATMENT

MEDICATION

  • No specific therapy exists for PIGN, and no randomized controlled trials indicate that aggressive immunosuppressive therapy has a beneficial effect in patients with rapidly progres...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Repeat urinalysis to check for clearance of hematuria and/or proteinuria.

  • Consider other diagnosis if no improvement within 2 weeks.

  • Recurrence is...

REFERENCES

1
Hunt EAK, Somers MJG. Infection-related glomerulonephritis. Pediatr Clin North Am.  2019;66(1):59–72. [View Abstract on OvidMedline]
2
Nasr SH, Radhakrishnan J, D’Agati VD. Bacterial in...

ADDITIONAL READING

  • Balasubramanian R, Marks SD. Post-infectious glomerulonephritis. Paediatr Int Child Health.  2017;37(4):240–247. [View Abstract on OvidMedline]

  • Glassock RJ, Alvarado A, Prosek J...

CODES

ICD10

  • N05.9 Unsp nephritic syndrome with unspecified morphologic changes

  • N00.9 Acute nephritic syndrome with unsp morphologic changes

ICD9

580.0 Acute glomerulonephritis with lesion of proliferative...

CLINICAL PEARLS

  • PIGN is an immune complex disease occurring after infection with certain strains of bacteria, most commonly group A Streptococcus pyogenes.

  • The clinical presentation varies from asympto...

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