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General Medicine

Granuloma Inguinale

Reviewed 06/2019
 


BASICS

DESCRIPTION

Granuloma inguinale is a primarily sexually transmitted, chronic bacterial infection caused by Klebsiella granulomatis (formerly Calymmatobacterium granulomatis or Donovania granulom...

DIAGNOSIS

HISTORY

  • Sexual contact ± genital lesions

  • Recent travel

  • History of HIV infection or other STIs

  • SC nodules or superficial blisters in the genital area that develop into open sores, usually painles...

TREATMENT

Usually can be treated in an outpatient setting with appropriate antibiotics and clinical monitoring 

GENERAL MEASURES

  • Empirical treatment should be comprehensive and cover all likely pathogen...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

If treated in a timely manner, lesions usually resolve. 

Patient Monitoring

  • Monitor for hyperkalemia with extended TMP/SMX treatment.

  • Other monitoring varies per tre...

REFERENCES

1
Richens J. Donovanosis (granuloma inguinale). Sex Transm Infect.  2006;82(Suppl 4):iv21–iv22. [View Abstract on OvidMedline]
2
Roett MA, Mayor MT, Uduhiri KA. Diagnosis and management o...

CODES

ICD10

A58 Granuloma inguinale 

ICD9

099.2 Granuloma inguinale 

SNOMED

  • 28867007 Granuloma inguinale (disorder)

  • 240607002 Donovanosis - inguinal lesion

  • 240606006 Donovanosis - anogenital ulcer

CLINICAL PEARLS

  • Presents as SC nodules or superficial blisters in the genital area that develop into open sores, usually painless

  • Unusual in the United States

  • The disease is transmitted usually through ...

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Related Images
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Calymmatobacterium granulomatis (Donovan body), the etiologic agent granuloma inguinale.
Calymmatobacterium granulomatis (Donovan body), the etiologic agent granuloma inguinale.
Granuloma inguinale.
Granuloma inguinale.
FIG. 32.3. Vulval granuloma inguinale of relatively recent origin. Some lesions are separate, others confluent. The margin of lesion is raised and scrolled; the base is granular and covered imperfectly by thin, gray slough. (From Demis DJ, Crounse RG, Dobson RL, et al, eds. Clinical dermatology, Vol 3. Hagerstown, MD: Harper & Row, 1972, with permission.)
FIG. 32.3. Vulval granuloma inguinale of relatively recent origin. Some lesions are separate, others confluent. The margin of lesion is rai...
Granuloma inguinale. A photomicrograph of a skin lesion shows C. granulomatis (Donovan bodies) clustered in a large macrophage. Intense silvering by Warthin-Starry technique makes the organisms large, black, and easily seen.
Granuloma inguinale. A photomicrograph of a skin lesion shows C. granulomatis (Donovan bodies) clustered in a large macrophage. Intense sil...
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