Skip to main content

Growth Hormone Deficiency

Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Insufficient production of growth hormone (GH) in adults or children caused by problems arising in the pituitary gland and/or hypothalamus

  • GH is produced by somatotroph cells of the a...

DIAGNOSIS

HISTORY

  • Children:

    • Poor height velocity, slower muscular development, and delayed gross motor milestones, such as standing, walking, and jumping

    • Clinical questions

      • Birth weight and length

      • Previous...

TREATMENT

MEDICATION

  • GHD is treated with GH replacement.

  • The goal of replacement therapy is to correct the metabolic, functional, and psychological abnormalities associated with GHD.

  • Recombinant human gr...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • Children: follow-up with a pediatric endocrinologist. Most endocrinologists will monitor growth and adjust dose every 3 to 6 months.

  • Childhood onset GHD: The need ...

REFERENCES

1
Fukuda I, Hizuka N, Muraoka T, et al. Adult growth hormone deficiency: current concepts. Neurol Med Chir (Tokyo).  2014;54(8):599–605. [View Abstract on OvidMedline]
2
Miller BS. rhGH s...

ADDITIONAL READING

  • Binder G. Growth hormone deficiency: new approaches to the diagnosis. Pediatr Endocrinol Rev.  2011;9(Suppl 1):535–537.

  • Cook DM, Yuen KC, Biller BM, et al. American Association ...

SEE ALSO

Pituitary Adenoma 

CODES

ICD10

E23.0 Hypopituitarism 

ICD9

  • 253.3 Pituitary dwarfism

  • 253.2 Panhypopituitarism

SNOMED

  • 397827003 Growth hormone deficiency (disorder)

  • 32390006 Panhypopituitarism (disorder)

  • 367460001 Pituitary dwarf...

CLINICAL PEARLS

  • Most common cause of GHD in children is idiopathic.

  • Most common cause of GHD in adults is a pituitary adenoma and/or treatment of the adenoma.

  • Most common presentation of childhood GHD i...

Subscribe to Access Full Content

Sign Up for a 10-Day Free Trial

Sign up for a 10-day FREE Trial now and receive full access to all content.

 
×