Insufficient production of growth hormone (GH) in adults or children are caused by problems arising in the pituitary gland and/or hypothalamus
GH is produced by somatotroph cells of t...
Children:
Poor height velocity, slower muscular development, and delayed gross motor milestones, such as standing, walking, and jumping
Clinical questions
Birth weight and length
Previous...
Childhood-onset GHD is treated with GH replacement, treatment should be started at the youngest possible age to achieve the greatest growth response. GH replacement is not recommen...
Children: monitor growth and adjust dose every 3 to 6 months.
Childhood onset GHD: The need for continuation of GH replacement should be evaluated following comple...
Kirk J. Indications for growth hormone therapy in children. Arch Dis Child. 2012;97(1):63–68. [View Abstract on OvidMedline]
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397827003 Growth hormone deficiency (disorder)
32390006 Panhypopituitarism (disorder)
367460001 Pituitary dwarfism
Most common cause of GHD in children is idiopathic.
Most common cause of GHD in adults is a pituitary adenoma and/or treatment of the adenoma.
Most common presentation of childhood GHD i...
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<bold>FIGURE 42-2</bold> Child with GH deficiency. A 5.5-year-old boy (<bold>left</bold>) with growth hormone deficiency was significantly shorter than his fraternal twin sister (<bold>right</bold>), with discrepancy beginning early in childhood. Notice his chubby immature appearance compared with his sister. (Shulman D., Bercu B. [2000]. <italic>Atlas of clinical endocrinology, neuroendocrinology, and pituitary diseases</bold> [edited by S. Korenman]. Philadelphia: Current Medicine)
<bold>FIGURE 42-2</bold> Child with GH deficiency. A 5.5-year-old boy (<bold>left</bold>) with growth hormone defi...