Insufficient production of growth hormone (GH) in adults or children caused by problems arising in the pituitary gland and/or hypothalamus
GH is produced by somatotroph cells of the a...
Children:
Poor height velocity, slower muscular development, and delayed gross motor milestones, such as standing, walking, and jumping
Clinical questions
Birth weight and length
Previous...
Childhood-onset GHD is treated with GH replacement. GH replacement is not recommended for adult-onset GHD.
The goal of replacement therapy is to correct the metabolic, functional, a...
Children: monitor growth and adjust dose every 3 to 6 months.
Childhood onset GHD: The need for continuation of GH replacement should be evaluated following comple...
Binder G. Growth hormone deficiency: new approaches to the diagnosis. Pediatr Endocrinol Rev. 2011;9(Suppl 1):535–537. [View Abstract on OvidMedlin...
397827003 Growth hormone deficiency (disorder)
32390006 Panhypopituitarism (disorder)
367460001 Pituitary dwarfism
Most common cause of GHD in children is idiopathic.
Most common cause of GHD in adults is a pituitary adenoma and/or treatment of the adenoma.
Most common presentation of childhood GHD i...
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<bold>FIGURE 42-2</bold> Child with GH deficiency. A 5.5-year-old boy (<bold>left</bold>) with growth hormone deficiency was significantly shorter than his fraternal twin sister (<bold>right</bold>), with discrepancy beginning early in childhood. Notice his chubby immature appearance compared with his sister. (Shulman D., Bercu B. [2000]. <italic>Atlas of clinical endocrinology, neuroendocrinology, and pituitary diseases</bold> [edited by S. Korenman]. Philadelphia: Current Medicine)
<bold>FIGURE 42-2</bold> Child with GH deficiency. A 5.5-year-old boy (<bold>left</bold>) with growth hormone defi...