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Guillain-Barré Syndrome

Grant M. Reed, DO and Simon B. Griesbach, MD Reviewed 06/2020
 


BASICS

DESCRIPTION

  • A group of acquired autoimmune disorders causing acute peripheral neuropathy and ascending paralysis that progressively worsens for up to 4 weeks followed by a slow spontaneous recov...

DIAGNOSIS

HISTORY

  • AIDP presents with onset of progressive limb weakness that reaches its worst within 4 weeks (73% reach a functional nadir in 1 week; 98% by 1 month).

  • Preceding respiratory or gastroint...

TREATMENT

GENERAL MEASURES

  • Consider admission to ensure that disease does not progress (respiratory function, autonomic stability, paralysis).

  • Supportive care is essential, paying close attention to com...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Patients require close monitoring of respiratory, cardiac, and hemodynamic function, typically in the ICU setting.

  • Pulmonary function testing (VC...

REFERENCES

1
Liu J, Wang LN, McNicol ED. Pharmacological treatment for pain in Guillain-Barré syndrome. Cochrane Database Syst Rev.  2015;(4):CD009950.
2
Hughes RA, Wijdicks EF, Benson E, et al; for...

ADDITIONAL READING

  • Sejvar JJ, Baughman AL, Wise M, et al. Population incidence of Guillain-Barré syndrome: a systematic review and meta-analysis. Neuroepidemiology.  2011;36(2):123–133.

  • Vellozzi C...

CODES

ICD10

G61.0 Guillain-Barré syndrome 

ICD9

357.0 Acute infective polyneuritis 

SNOMED

40956001 Guillain-Barre syndrome (disorder) 

CLINICAL PEARLS

  • Suspect GBS in cases of ascending flaccid paralysis with areflexia and an antecedent history of viral respiratory illness or gastroenteritis.

  • When GBS is suspected, evaluate VC and insp...

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