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Hamartoma

Gemma Kim, MD, Tae K Kim, MD and Bao T Huynh, MD Reviewed 04/2024
 


BASICS

DESCRIPTION

  • Hamartoma was first described by Albrecht in 1904.

  • Defined as nonneoplastic disorganized growths of native cells in native tissues

  • Can occur in many different organs, including bile du...

DIAGNOSIS

HISTORY

  • Lung hamartomas are often incidental findings on imaging and can mimic pulmonary malignancies. On imaging, e.g., chest X-ray or CT scans, masses present as coin- shaped and solitary, ...

TREATMENT

  • Pulmonary Hamartoma

    • Wedge resection is the treatment of choice for patients with pulmonary hamartoma.

    • Aggressive lobectomy or total pneumectomy is also an option in some cases.

  • Hypothalamic Ham...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Continued surveillance for patients at higher risk of malignancy (e.g., Peutz-Jeghers, Cowden syndromes); annual follow-up postresection of HH to assess seizure c...

REFERENCES

1
Yehia L, Eng C. PTEN Hamartoma Tumor Syndrome. 2001 Nov 29 [Updated 2021 Feb 11]. In: Adam MP, Mirzaa GM, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Wa...

ADDITIONAL READING

SEE ALSO

Hemangiomas and Other Vascular Lesions, Pediatric; Peutz-Jeghers Syndrome; Tuberous Sclerosis Complex; Uterine Myomas 

CODES

ICD10

Q85.9 Phakomatosis, unspecified 

SNOMED

  • 400006008 hamartoma (disorder)

  • 254644003 hamartoma of lung (disorder)

  • 277369003 Hamartoma of brain

  • 268284006 vascular hamartomas (disorder)

  • 253810002 Liver...

CLINICAL PEARLS

  • Hamartomas are disorganized growths of native cells in native tissues. Symptoms vary with tissue of origin; many are found incidentally.

  • The majority is benign; malignant transformation...

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