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Henoch-Schönlein Purpura

Shani I. Muhammad, MD Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Henoch-Schönlein purpura (HSP) is a nonthrombocytopenic, predominantly IgA-mediated, small vessel vasculitis that affects multiple organ systems and occurs in both children and adult...

DIAGNOSIS

Palpable purpura and at least one of the following: 
  • Diffuse abdominal pain

  • Biopsy with predominant IgA deposition

  • Arthralgia or arthritis

  • Renal involvement (hematuria or proteinuria)

  • Direct immu...

TREATMENT

GENERAL MEASURES

Rest and elevation of affected areas may limit purpura. 

MEDICATION

  • In the absence of renal dysfunction or complication, HSP is usually self-limited and best managed with suppo...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Patients should be seen weekly during the acute illness. Visits should include history and physical exam to include BP measurement and urinalysi...

REFERENCES

1
Kutlubay Z, Zara T, Engin B, et al. Helicobacter pylori infection and skin disorders. Hong Kong Med J.  2014;20(4):317–324. [View Abstract on OvidMedline]
2
Mysorekar VV, Sumathy TK, Sh...

ADDITIONAL READING

  • Batu ED, Ozen S. Pediatric vasculitis. Curr Rheumatol Rep.  2012;14(2):121–129. [View Abstract on OvidMedline]

  • Boulis E, Majithia V, McMurray R. Adult-onset Henoch-Schonlein pur...

CODES

ICD10

D69.0 Allergic purpura 

ICD9

287.0 Allergic purpura 

SNOMED

  • 191306005 Henoch-Schonlein purpura (disorder)

  • 239946005 Postinfective Henoch-Schnlein purpura

CLINICAL PEARLS

  • HSP is a systemic small vessel vasculitis characterized by clinical tetrad of palpable purpura, abdominal pain, arthralgia, and renal dysfunction.

  • The main form of treatment is supporti...

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