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Hepatitis C

Matthew B. Nodelman, M.D. and Morgan Adams Rhodes, PharmD Reviewed 04/2024
 


BASICS

DESCRIPTION

Systemic viral infection involving the liver 

EPIDEMIOLOGY

Geriatric Considerations

Patients >60 years may be less responsive to therapy, as they are more likely to have advanced fib...

DIAGNOSIS

HISTORY

  • Determine exposure risk: detailed social history, including alcohol and IV drug use, psychiatric and medical comorbidities, and coinfections.

  • Chronic HCV: Most cases are mildly symptom...

TREATMENT

GENERAL MEASURES

  • Goal is to achieve SVR, reduce adverse events (including progression to cirrhosis and hepatocellular carcinoma) and all-cause mortality.

  • Report acute HCV to state health depar...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • Serial viral loads are normally not required, unless a patient has inadequate medication adherence, but all patients treated should have a viral load completed 12...

REFERENCES

1
Schillie S, Wester C, Osborne M, et al. CDC recommendations for hepatitis c screening among adults—United States, 2020. MMWR Recomm Rep. 2020;69(2):1–17.
2
Ghany MG, Morgan TR. Hepatitis C ...

SEE ALSO

  • Cirrhosis of the Liver; Hepatitis A; Hepatitis B; HIV/AIDS

  • Algorithm: Hyperbilirubinemia and Jaundice

  • www.hcvguidelines.org

CODES

ICD10

  • B19.20 Unspecified viral hepatitis C without hepatic coma

  • B17.10 Acute hepatitis C without hepatic coma

  • B18.2 Chronic viral hepatitis C

SNOMED

  • 50711007 Viral hepatitis C (disorder)

  • 235866006 Acu...

CLINICAL PEARLS

  • HCV is the most common cause of HCC in the western world. Genotype 1 is most common GT in the United States.

  • 1 of 10 patients with HCV has no identifiable risk factors; 15–25% of HCV-in...

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