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Hepatitis C

Anqi Li and Alhang Konyak, MD, FAAFP Reviewed 06/2022
 


BASICS

DESCRIPTION

Systemic viral infection involving the liver 

EPIDEMIOLOGY

Geriatric Considerations

Patients >60 years are less responsive to therapy (1,2)

 
Pregnancy Considerations
  • Routine prenatal ...

DIAGNOSIS

HISTORY

  • Determine exposure risk: detailed social history, including alcohol and IV drug use, psychiatric and medical comorbidities, and coinfections.

  • Chronic HCV: Most cases are mildly symptom...

TREATMENT

GENERAL MEASURES

  • Goal is to achieve sustained virologic response (SVR), reduce adverse events and all-cause mortality.

  • Report acute HCV to state health department.

  • Treat all patients with virol...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • Monitor serial viral load only if on antiviral therapy.

  • AASLD and IDSA now recommend an abdominal US every 6 months, with or without serum α-fetoprotein (AFP) to m...

REFERENCES

1
Hofmeister MG, Rosenthal EM, Barker LK, et al. Estimating prevalence of hepatitis c virus infection in the United States, 2013–2016. Hepatology. 2019;69(3):1020–1031.
2
Schillie S, Wester C,...

SEE ALSO

CODES

ICD10

  • B19.20 Unspecified viral hepatitis C without hepatic coma

  • B17.10 Acute hepatitis C without hepatic coma

  • B18.2 Chronic viral hepatitis C

SNOMED

  • 50711007 Viral hepatitis C (disorder)

  • 235866006 Acu...

CLINICAL PEARLS

  • HCV is the most common cause of HCC in the western world.

  • GT 1 is the most common GT of HCV in the U.S.

  • 1 of 10 patients with HCV has no identifiable risk factors; 15–25% of HCV-infected...

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