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Hepatoma (Hepatocellular Carcinoma)

Reviewed 06/2019
 


BASICS

DESCRIPTION

Hepatoma, also known as hepatocellular carcinoma (HCC), is the most common primary malignant tumor of the liver, arising from hepatic parenchymal cells (hepatocytes); 80% are associa...

DIAGNOSIS

  • In children

    • Feminization, precocious puberty

    • Palpable liver mass, pain, asymmetrical hepatomegaly

  • In adults

    • Known cirrhosis or clinical signs of cirrhosis: 80%

    • Abdominal pain: 80%; right uppe...

TREATMENT

MEDICATION

  • Targeted therapy with sorafenib offers a small survival benefit in patients with disease not amenable to surgical intervention; not effective as adjunctive to surgery (7)[B]

  • Treatme...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

Even after successful resection, there is a high risk of recurrence. 
  • AFP level every 3 months

  • US every 4 to 6 months or contrast-enhanced CT/MRI ...

REFERENCES

1
Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet.  2012;379(9822):1245–1255. [View Abstract on OvidMedline]
2
Cha CH, Saif MW, Yamane BH, et al. Hepatocellular carcinoma: ...

ADDITIONAL READING

CODES

ICD10

C22.0 Liver cell carcinoma 

ICD9

155.0 Malignant neoplasm of liver, primary 

SNOMED

95214007 Primary malignant neoplasm of liver 

CLINICAL PEARLS

  • With benign liver tumors, most patients will have normal LFTs; 97% with HCC will have >1 abnormal test.

  • Hepatitis C is the greatest risk factor, especially if combined with alcohol a...

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