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Herpes Simplex

Simone Prioli, BS, MPAS, PA-C and Ekaterina Brodski-Quigley, M.D., Ed.M. Reviewed 06/2022
 


BASICS

DESCRIPTION

  • Characteristic vesicular rash primarily located in oral and genital regions caused by infection with:

    • HSV-1: blisters mostly on lips, in mouth, face, eyes

    • HSV-2: blisters primarily on ...

DIAGNOSIS

HISTORY

  • Many patients are unaware of a known exposure.

  • Prodrome of fatigue, low-grade fever, itching, tingling, or hot skin for several days prior to primary outbreak of characteristic vesicul...

TREATMENT

GENERAL MEASURES

  • Symptom management while lesions heal

  • Cool dressings moistened with aluminum acetate solution

  • For genital lesions: Pour a cup of warm water over genitals while urinating or by ...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • For most routine cases, follow-up is not necessary. Lesions and symptoms resolve rapidly within 10 days. Extensive cases should be rechecked in 1 week; monitor fo...

REFERENCES

1
Sauerbrei  A. Optimal management of genital herpes: current perspectives. Infect Drug Resist.  2016;9:129–141. [View Abstract on OvidMedline] ...

ADDITIONAL READING

  • Devanand DP, Andrews H, Kreisl WC, et al. Antiviral therapy: Valacyclovir Treatment of Alzheimer's Disease (VALAD) Trial: protocol for a randomised, double-blind, placebo...

SEE ALSO

  • Herpes, Genital

  • Algorithm: Genital Ulcers

CODES

ICD10

  • B00 Herpesviral [herpes simplex] infections

  • B00.0 Eczema herpeticum

  • B00.1 Herpesviral vesicular dermatitis

  • B00.2 Herpesviral gingivostomatitis and pharyngotonsillitis

  • B00.3 Herpesviral meningit...

CLINICAL PEARLS

  • Up to 25–30% of the U.S. population has serologic evidence of genital herpes (HSV-2), and >80% is seropositive for HSV-1.

  • Most individuals are unaware they are infected, allowing for...

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